Dopamine transporters increase in human brain after alcohol withdrawal
Dopamine transporters increase in human brain after alcohol withdrawal
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DOI：
10.1038/sj.mp.4000514
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发表时间：
1999-03-01
影响因子：
11
通讯作者：
Hillbom, M
中科院分区：
文献类型：
--
作者：
Laine, TPJ;Ahonen, A;Hillbom, M
多巴胺能传递被认为是与酒精成瘾相关的强化、戒断和渴求的主要机制。我们用单光子发射计算机断层扫描(SPECT)技术，用可卡因类似物碘-123β-CIT测定了27例酗酒者戒酒后4天内和戒酒4周后纹状体多巴胺(DA)转运体的结合。对照组为29名健康志愿者。SPECT数据的盲法定量分析显示，酒精者入院戒毒时DA转运蛋白结合量明显低于非酒精者对照组。戒酒4周后，酒精组(P<；0.0001)DA转运体结合量显着增加，接近健康对照组水平。DA转运体结合的最显著恢复发生在禁欲的前4天。数据表明，长期大量饮酒降低了DA转运体的结合，并扰乱了突触多巴胺的运输。这可能会使酗酒者对多巴胺能传递敏感，这可能会导致酒精戒断后早期复发。
Dopaminergic transmission has been suggested to be a main mechanism mediating reinforcement, withdrawal and craving associated with alcohol addiction. We measured here striatal dopamine (DA) transporter binding from 27 alcoholics within 4 days after cessation of prolonged heavy drinking and after a 4-week period of abstinence with single photon emission computed tomography (SPECT) using a cocaine analogue, iodine-123 beta-CIT. Controls were 29 healthy volunteers. Blind quantitative analyses of the SPECT data revealed markedly lower DA transporter binding in alcoholics on admission for detoxification than in the non-alcoholic controls. After a 4-week period of abstinence DA transporter binding increased significantly in the alcoholics (P < 0.0001) reaching the levels of the healthy controls. The most substantial recovery in DA transporter binding occurred during the first 4 days of abstinence. The data indicate that prolonged heavy drinking decreases DA transporter binding and distrubs synaptic dopamine transport. This may sensitize alcoholics to dopaminergic transmission, which may lead to early relapse after ethanol withdrawal.