Recent advances in peptide-based subunit nanovaccines.
Recent advances in peptide-based subunit nanovaccines.
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DOI：
10.2217/nnm.14.187
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发表时间：
2014-12
期刊：
影响因子：
5.5
通讯作者：
M. Skwarczynski;I. Toth
中科院分区：
文献类型：
--
作者：
M. Skwarczynski;I. Toth
接种疫苗是保护人类免受病原体侵害的最有效方法。基于肽的疫苗与利用整个生物体或蛋白质的经典疫苗相比具有几个优点。然而，肽本身不是免疫原性的，需要一个可以增强免疫系统对其识别的递送系统。近年来，基于纳米技术的方法已成为肽疫苗递送中最有前途的策略之一。这篇综述总结了肽疫苗和纳米技术为基础的方法，他们的交付知识。综述了近年来报道的肽抗原纳米载体，包括由聚合物、肽、脂质、无机材料和纳米管组成的纳米载体。展望了基于肽的纳米疫苗的发展前景。
Vaccination is the most efficient way to protect humans against pathogens. Peptide-based vaccines offer several advantages over classical vaccines, which utilized whole organisms or proteins. However, peptides alone are not immunogenic and need a delivery system that can boost their recognition by the immune system. In recent years, nanotechnology-based approaches have become one of the most promising strategies in peptide vaccine delivery. This review summarizes knowledge on peptide vaccines and nanotechnology-based approaches for their delivery. The recently reported nano-sized delivery platforms for peptide antigens are reviewed, including nanoparticles composed of polymers, peptides, lipids, inorganic materials and nanotubes. The future prospects for peptide-based nanovaccines are discussed.