Epidemiologic Characteristics of Intraocular Pressure in the Korean and Mongolian Populations: The Healthy Twin and the GENDISCAN Study
Epidemiologic Characteristics of Intraocular Pressure in the Korean and Mongolian Populations: The Healthy Twin and the GENDISCAN Study
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DOI：
10.1016/j.ophtha.2011.09.016
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发表时间：
2012-03-01
期刊：
影响因子：
13.7
通讯作者：
Sung, Joohon
中科院分区：
文献类型：
--
作者：
Lee, Mi Kyeong;Cho, Sung-Il;Sung, Joohon
目的：本研究的目的是在2个亚洲人群中证明眼内压（IOP）与年龄之间的负相关性。此外，我们评估了与IOP相关的遗传和非遗传因素。设计：以家庭为基础的队列研究。参与者：研究对象>10岁，来自一个韩国人（健康双胞胎; n = 1431）和两个蒙古族人群（GENDISCAN; n = 859和806）与IOP values.Methods：IOP值测量与非接触式眼压计。每位参与者都接受了标准的健康检查并接受了问卷调查，其中包括IOP的候选风险因素。使用混合模型来识别IOP的风险因素。方差分量法估计的遗传力的IOP.Main结果措施：随着年龄的增长和评估的影响，遗传和非遗传成分对IOP.Results：的IOP的负趋势，平均年龄分别为43.6，34.1，和36.3岁的韩国，Orhontuul，和Dashbalbar人群，分别。韩国人群的平均IOP为14.4 mmHg（95%置信区间[CI]，14.3-14.6），Orhontuul和Dashbalbar人群分别为14.1 mmHg（95% CI，13.9-14.3）和12.6 mmHg（95% CI，12.4-12.9）。在3个人群中，IOP随年龄的增加而降低。我们复制了收缩压（SBP）与IOP的相关性。此外，代谢综合征（MS）的组成部分，如血糖、血脂水平和体重指数，在调整年龄和SBP后，与IOP呈正相关。IOP在所有人群中也有很强的遗传贡献（遗传度，0.47-0.51）。结论：在所有3个人群中观察到年龄与IOP之间的负相关，这不能用年轻一代近视患病率的增加来解释。IOP的不同年龄趋势可能是青光眼亚型患病率差异的部分原因。我们的研究结果表明，IOP和MS组分之间的关联独立于已确定的风险因素，如SBP或年龄。此外，遗传风险的重要性，需要进一步的遗传解剖的IOP决定因素的生物学理解的基础pathophysiology.Financial披露（S）：作者没有专有或商业利益的任何材料在本文中讨论。Ophthalmology 2012;119：450-457（C）2012，美国眼科学会。
Purpose: The purpose of this study was to demonstrate a negative association between intraocular pressure (IOP) and age in 2 Asian populations. In addition, we evaluated genetic and nongenetic factors associated with IOP.Design: Family-based cohort study.Participants: Study subjects >10 years of age from one Korean (The Healthy Twin; n = 1431) and 2 Mongolian populations (The GENDISCAN; n = 859 and 806) with IOP values.Methods: The IOP values were measured with a noncontact tonometer. Each participant received a standard health examination and received questionnaires, which include candidate risk factors on IOP. Mixed models were used to identify risk factors for IOP. Variance-component methods were applied to estimate the heritability of IOP.Main Outcome Measures: The negative trend of IOP with aging and evaluation of impact of genetic and nongenetic components on IOP.Results: The mean ages were 43.6, 34.1, and 36.3 years for the Korean, Orhontuul, and Dashbalbar populations, respectively. The mean IOPs were 14.4 mmHg (95% confidence interval [CI], 14.3-14.6) in the Koreans and 14.1 mmHg (95% CI, 13.9-14.3) and 12.6 mmHg (95% CI, 12.4-12.9) in the Orhontuul and Dashbalbar populations, respectively. In the 3 populations, the IOP decreased as age increased. We replicated an association of systolic blood pressure (SBP) with IOP. In addition, components of the metabolic syndrome (MS), such as plasma glucose, lipid level, and body mass index, showed positive associations with IOP, after adjusting for age and SBP. The IOP also had strong genetic contributions in all populations (heritability, 0.47-0.51).Conclusions: Negative associations between age and IOP were observed in all 3 populations, which cannot be explained by the increasing prevalence of myopia in the younger generation. The different age trend in IOP may in part be responsible for differences in the prevalence of glaucoma subtypes. Our findings suggest that associations between IOP and MS components were independent of established risk factors such as SBP or age. In addition, the importance of inherited risks requires further genetic dissection of IOP determinants for biological understandings of underlying pathophysiology.Financial Disclosure(s): The authors have no proprietary or commercial interest in any materials discussed in this article. Ophthalmology 2012;119:450-457 (C) 2012 by the American Academy of Ophthalmology.