Neuronal CC chemokines: the distinct roles of CCL21 and CCL2 in neuropathic pain.
Neuronal CC chemokines: the distinct roles of CCL21 and CCL2 in neuropathic pain.
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DOI：
10.3389/fncel.2014.00210
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发表时间：
2014
影响因子：
5.3
通讯作者：
Boddeke E
中科院分区：
文献类型：
--
作者：
Biber K;Boddeke E
周围神经损伤后神经病理性疼痛的发生在很大程度上依赖于位于脊髓背角的小胶质细胞。因此，受损的神经启动小胶质细胞的反应，这代表了导致神经性疼痛发展的级联事件的开始。很长一段时间以来，周围神经损伤如何引发脊髓背角的小胶质细胞反应仍然不清楚。最近，两种趋化因子已被认为是介导受损神经元和小胶质细胞之间通信的潜在因子，即CCL 2和CCL 21。这一假设基于以下调查结果。这两种趋化因子在健康神经元中均未发现，但在神经元损伤时表达。在受伤的背根神经节细胞中，CCL 2和CCL 21在索马的囊泡中表达，并通过背根轴突转运到脊髓背角。最后，已知体外小胶质细胞对CCL 2和CCL 21有反应。尽管参与CCL 21诱导的神经病理性疼痛的小胶质细胞趋化因子受体尚未确定，但关于体内小胶质细胞中CCL 2受体的情况甚至更不清楚。最近在转基因动物中获得的结果清楚地表明，小胶质细胞在体内不表达CCR 2，但外周骨髓细胞和神经元表达。这表明与CCL 21相反，由受损背根神经元表达的CCL 2不充当神经元-小胶质细胞信号。相反，损伤的背根神经节（DRG）中的CCL 2可以充当自分泌或旁分泌信号，并且可以刺激疼痛级联中的一级或二级神经元和/或将表达CCR 2的外周单核细胞/巨噬细胞吸引到脊髓。
The development of neuropathic pain in response to peripheral nerve lesion for a large part depends on microglia located at the dorsal horn of the spinal cord. Thus the injured nerve initiates a response of microglia, which represents the start of a cascade of events that leads to neuropathic pain development. For long it remained obscure how a nerve injury in the periphery would initiate a microglia response in the dorsal horn of the spinal cord. Recently, two chemokines have been suggested as potential factors that mediate the communication between injured neurons and microglia namely CCL2 and CCL21. This assumption is based on the following findings. Both chemokines are not found in healthy neurons, but are expressed in response to neuronal injury. In injured dorsal root ganglion cells CCL2 and CCL21 are expressed in vesicles in the soma and transported through the axons of the dorsal root into the dorsal horn of the spinal cord. Finally, microglia in vitro are known to respond to CCL2 and CCL21. Whereas the microglial chemokine receptor involved in CCL21-induced neuropathic pain is not yet defined the situation concerning the receptors for CCL2 in microglia in vivo is even less clear. Recent results obtained in transgenic animals clearly show that microglia in vivo do not express CCR2 but that peripheral myeloid cells and neurons do. This suggests that CCL2 expressed by injured dorsal root neurons does not act as neuron-microglia signal in contrast to CCL21. Instead, CCL2 in the injured dorsal root ganglia (DRG) may act as autocrine or paracrine signal and may stimulate first or second order neurons in the pain cascade and/or attract CCR2-expressing peripheral monocytes/macrophages to the spinal cord.
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DOI：
10.1523/jneurosci.3295-09.2010
发表时间：
2010-01-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Clark AK;Staniland AA;Marchand F;Kaan TK;McMahon SB;Malcangio M
通讯作者：
Malcangio M
影响因子：
3.3
作者：
Bhangoo SK;Ripsch MS;Buchanan DJ;Miller RJ;White FA
通讯作者：
White FA
影响因子：
2.7
作者：
Clark AK;Old EA;Malcangio M
通讯作者：
Malcangio M
影响因子：
6.2
作者：
Biber, K;Sauter, A;Boddeke, HWGM
通讯作者：
Boddeke, HWGM
DOI：
10.1073/pnas.0602620103
发表时间：
2006-05-23
影响因子：
11.1
作者：
Callewaere, Celine;Banisadr, Ghazal;Parsadaniantz, Stephane Melik
通讯作者：
Parsadaniantz, Stephane Melik