Cryoblockade of the ventromedial frontal cortex reverses hypertension in the rat.
Cryoblockade of the ventromedial frontal cortex reverses hypertension in the rat.
复制标题
腹内侧额叶皮质的冷冻阻断可逆转大鼠的高血压。
DOI：
10.1161/01.hyp.9.6.576
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Skinner,JE
中科院分区：
文献类型：
--
作者：
Szilagyi,JE;Taylor,AA;Skinner,JE
与第三脑室相邻的下丘脑前腹侧部分（AV3V）在电解损伤研究中被认为是高血压发展和维持的关键部位。已知低温阻断在不同温度下对突触和轴突传递的改变不同。在这项研究中，将下丘脑（包括AV3V区域）冷却到已知仅阻断突触功能的温度，并没有改变两种不同的大鼠实验性高血压模型的血压。然而，冷却到足以阻断突触和轴突传递，将血压升高降低到接近正常水平。前额皮质腹内侧区突触低温阻断使实验高血压降低21 +/- 3 mm Hg （p < 0.05）。在正常血压的对照组中，额叶皮质和下丘脑的低温阻断均未改变血压。其他人提供的解剖学证据表明，腹内侧额叶皮层的细胞部分通过AV3V区域投射到脑干心脏调节结构。这些结果表明，在实验性高血压中，额叶皮层产生的神经活动通过轴向投射到下丘脑以维持升高的血压。
The anteroventral part of the hypothalamus adjacent to the third ventricle (AV3V) has been implicated in electrolytic lesion studies as a site crucial to the development and maintenance of hypertension. Cryoblockade is known to alter synaptic and axonal transmission differently at different temperatures. In this study, cooling of the hypothalamus, including the AV3V area, to the temperature known to block only synaptic function did not alter blood pressure in two different models of experimental hypertension in the rat. Cooling sufficient to block both synaptic and axonal transmission, however, reduced blood pressure elevations to near normotensive levels. Synaptic cryoblockade in the ventromedial portion of the frontal cortex lowered experimental hypertension by 21 +/- 3 mm Hg (p less than 0.05). In normotensive controls, blood pressure was not altered by cryoblockade in either the frontal cortex or hypothalamus. Anatomical evidence provided by others shows that cells in the ventromedial frontal cortex project, in part, through the AV3V region to the brainstem cardioregulatory structures. These results indicate that neural activity arising in frontal cortex is axonally projected through the hypothalamus to maintain elevated blood pressure in experimental hypertension.