Health surveillance in the population living in a methyl mercury-polluted area over a long period.
Health surveillance in the population living in a methyl mercury-polluted area over a long period.
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长期居住在甲基汞污染地区人群的健康监测。
DOI：
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发表时间：
2000
影响因子：
8.3
通讯作者：
K. Miyamoto
中科院分区：
文献类型：
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作者：
M. Futatsuka;T. Kitano;M. Shono;Yoshiharu Fukuda;Kayo Ushijima;T. Inaoka;M. Nagano;J. Wakamiya;K. Miyamoto
跟踪水俣市周边甲基汞污染地区居民的健康状况非常重要，不仅要特别关注中枢神经系统疾病，还要关注其他器官的疾病。十多年来，我们一直在进行这样的同心研究。我们之前研究了水俣病患者的特定原因标准死亡率，并报道男性和女性患者的肝脏疾病和肾脏疾病的 SMR 分别显着升高。调查还发现，糖尿病引起的并发症可能是由于尸检病例中老年人较多所致。下一步是从流行病学角度明确该地区人群肝病、肾病和糖尿病的实际患病率和发病率。本研究的目的是确定这些疾病和主诉的实际患病率，并调查该地区各种危险因素对这些疾病的影响。该研究是一项基于人群的横断面大规模筛查调查。病例对照研究旨在评估各种危险因素（包括甲基汞暴露）对这些疾病的影响。自1984年起，每年夏天，在邻近水俣市的纲町，都会对1500名40岁以上的受试者进行大规模多重健康检查。纲町位于甲基汞污染地区，每1000人中有36.9名水俣病患者。根据尿液、血液学、体检和超声检查收集有关肝脏疾病、肾脏疾病和糖尿病的数据。通过访谈和其他措施收集有关风险因素和主观投诉的数据。与日本其他地区相比，该甲基汞污染地区的这些疾病的患病率并不高，这与根据标准死亡率和病理结果的预期相反。这些疾病与甲基汞暴露之间没有正相关关系。另一方面，污染地区的居民比非污染地区的居民提出的投诉更多、种类也更多。不仅神经系统主观主诉可能受到过去甲基汞暴露的影响，污染地区人群的非特异性主诉也可能受到影响。今后必须继续对居住在甲基汞污染地区的人口进行健康监测。
It is important to follow up on the health status of inhabitants living in the methyl mercury-polluted area surrounding Minamata City, paying particular attention to diseases not only of the central nervous system but also of other organs. We have been carrying out such concentric studies for more than 10 years. We have previously studied the cause-specific standard mortality ratios in Minamata disease patients and reported that the SMRs for liver disease and renal disease were significantly raised in male and female patients, respectively. It was also found that complications arising from diabetes could be due to the large number of old people among the autopsy cases. The next step was to clarify the actual prevalence and incidence of liver disease, renal disease, and diabetes mellitus epidemiologically among the population in this area. The aim of this study was to determine the actual prevalence of these diseases and complaints, and to investigate the contribution of various risk factors to these diseases in this area. The study was a population-based cross-sectional mass screening survey. A case-control study was designed to estimate the role of various risk factors including methyl mercury exposure for these diseases. A mass multiple health examination survey was performed in 1500 subjects aged 40 years and older in Tsunagi Town, neighboring Minamata City, every summer since 1984. Tsunagi Town is located in a methyl mercury-polluted area and there are 36.9 certified Minamata disease patients per 1000 population. Data concerning liver disease, renal disease, and diabetes mellitus were collected on the basis of urine, hematological, physical, and ultrasonographic examinations. Data on risk factors and subjective complaints were collected by interview and other measures. The prevalence of these diseases was not higher in this methyl mercury-polluted area compared with other areas in Japan, contrary to what was expected based on standard mortality ratios and pathological findings. There were no positive correlations between those diseases and methyl mercury exposure. On the other hand, the population in the polluted area had more and a greater variety of complaints than those in the nonpolluted area. It is possible that not only neurological subjective complaints but also nonspecific complaints of the population in the polluted area might be influenced by past methyl mercury exposure. This health surveillance in the population living in a methyl mercury-polluted area must be maintained in the future.
兔肾近曲小管细胞的原代培养。
影响因子：
3.8
作者：
Aleo,MD;Taub,ML;Kostyniak,PJ
通讯作者：
Kostyniak,PJ