New aspects of DNA adduct formation by the carcinogens crotonaldehyde and acetaldehyde.
New aspects of DNA adduct formation by the carcinogens crotonaldehyde and acetaldehyde.
复制标题
致癌物质巴豆醛和乙醛形成 DNA 加合物的新方面。
DOI：
10.1007/978-1-4615-0667-6_7
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发表时间：
2001
影响因子：
--
通讯作者：
Wang,M
中科院分区：
文献类型：
--
作者：
Hecht,SS;McIntee,EJ;Cheng,G;Shi,Y;Villalta,PW;Wang,M
巴豆醛和乙醛在S中具有诱变性。鼠伤寒杆菌和其他用于检测遗传损伤的系统（IARC，1985；1995；1999）。 F344大鼠口服巴豆醛后，可诱导肝细胞病灶改变、肿瘤结节和肝细胞癌（Chung等人，1986；IARC，1995）。吸入乙醛会导致大鼠和仓鼠呼吸道肿瘤（IARC，1985；1999）。巴豆醛和乙醛通常在香烟烟雾、移动源排放物和其他热降解产物中检测到（IARC，1985；1995；1999）。与被认为是香烟烟雾中重要致癌物的多环烃、芳香胺和N-亚硝胺相比，它们在香烟烟雾中的浓度要高得多，而其致癌活性却要低得多（IARC，1985；1986；1995；1999）。巴豆醛和乙醛也是重要的内源性化合物。巴豆醛是脂质过氧化的产物，而乙醛是乙醇的主要代谢物。
Crotonaldehyde and acetaldehyde are mutagenic inS. typhimuriumand other systems used for detection of genetic damage (IARC, 1985; 1995; 1999). Crotonaldehyde induces altered liver cell foci, neoplastic nodules, and hepatocellular carcinoma upon oral administration to F344 rats (Chung et al, 1986; IARC, 1995). Acetaldehyde causes tumors of the respiratory tract in rats and hamsters upon exposure by inhalation (IARC, 1985; 1999). Crotonaldehyde and acetaldehyde are commonly detected in cigarette smoke, mobile source emissions and other products of thermal degradation (IARC, 1985; 1995; 1999). Their concentrations in cigarette smoke are far higher, while their carcinogenic activities are considerably lower, than those of polycyclic hydrocarbons, aromatic amines and N-nitrosamines, which are considered to be important carcinogens in cigarette smoke (IARC, 1985; 1986; 1995; 1999). Crotonaldehyde and acetaldehyde are also important endogenous compounds. Crotonaldehyde is a product of lipid peroxidation while acetaldehyde is the principal metabolite of ethanol.