Metabolic syndrome contributes to cognitive impairment in patients with Parkinson's disease
Metabolic syndrome contributes to cognitive impairment in patients with Parkinson's disease
复制标题
代谢综合征导致帕金森病患者认知功能障碍
DOI：
10.1016/j.parkreldis.2018.05.013
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发表时间：
2018-10-01
影响因子：
4.1
通讯作者：
Zhou, Huadong
中科院分区：
文献类型：
--
作者：
Peng, Zeyan;Dong, Shuyang;Zhou, Huadong
前言：代谢综合征(METS)会增加正常衰老时认知损害的风险，但这在帕金森病(PD)中尚未被研究。本研究旨在探讨蛋氨酸对糖尿病认知功能损害的影响。方法：本研究调查了60岁以上被诊断为帕金森病患者。他们在2010年1月至2011年12月期间参加了这项研究，并跟踪调查了5年。对帕金森病患者的认知功能的评估以认知和神经精神测试为基础，并根据国家胆固醇教育计划的成人治疗小组III进行诊断。根据随访结束时的认知功能将受试者分为三组：认知功能正常的帕金森病患者(PD-NC)、轻度认知功能障碍的帕金森病患者(PD-MCI)和帕金森病患者(PDD)。结果：787例帕金森病患者中，255例(32.4%)被诊断为PD-MCI，105例(13.3%)被诊断为PDD。METS与PD-MCI(优势比[OR]：1.45，95%可信区间[CI]：1.17~1.72)和PDD(OR：2.12，95%CI：1.57~2.83)显著相关。METS与PDD的主要认知领域之间的相关性具有统计学意义。结论：甲硫氨酸可增加帕金森病患者认知功能障碍的风险，且与认知功能障碍的严重程度显著相关。结果提示，对甲硫氨酸的干预有助于控制帕金森病患者的认知功能障碍。
Introduction: Metabolic syndrome (MetS) increases the risk of cognitive impairment in normal aging but this has not been studied in Parkinson's Disease (PD). The purpose of this study was to investigate the impact of MetS on cognitive impairment in PD.Methods: This study investigated subjects older than 60 years who were diagnosed with PD. They were enrolled into this study between January 2010 and December 2011, and followed for 5 years. The assessment of cognitive function in subjects with PD was based on the cognitive and neuropsychiatric tests, and MetS was diagnosed according to the National Cholesterol Education Program's Adult Treatment Panel III. The subjects were divided into three groups according to the cognitive function at the end of follow-up: PD with normal cognitive function (PD-NC), mild cognitive impairment in PD (PD-MCI) and PD dementia (PDD).Results: Of the 787 subjects with PD included in our study, 255 (32.4%) were diagnosed with PD-MCI, and 105 (13.3%) were diagnosed with PDD. MetS was significantly associated with PD-MCI (odds radio [OR]: 1.45, 95% confidence interval [CI]: 1.17-1.72) and PDD (OR: 2.12, 95% CI: 1.57-2.83). The associations between MetS and the main cognition domains of PDD were statistically significant. The treatment of MetS was helpful in reducing the risk of PDD.Conclusions: We found that MetS increase the risk of cognitive impairment in patients with PD, and is significantly associated with the severity of cognitive impairment. The results suggest that the intervention against MetS is helpful in managing cognitive impairment in PD.