How (specific) would like your T-cells today? Generating T-cell therapeutic function through TCR-gene transfer.
How (specific) would like your T-cells today? Generating T-cell therapeutic function through TCR-gene transfer.
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DOI：
10.3389/fimmu.2012.00186
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发表时间：
2012
影响因子：
7.3
通讯作者：
Cohen CJ
中科院分区：
文献类型：
--
作者：
Daniel-Meshulam I;Ya'akobi S;Ankri C;Cohen CJ
T细胞是针对病原体和癌症的免疫反应的核心参与者。它们的特异性仅由它们克隆表达的T细胞受体（TCR）决定。因此，使用病原体或癌症特异性TCR对T淋巴细胞进行遗传修饰代表了从外周血淋巴细胞产生所需免疫应答的吸引人的策略。此外，在最近进行的几项临床试验中，在用TCR基因修饰的细胞治疗的晚期癌症患者中观察到显著的客观临床应答。然而，这一方法的几个关键方面是深入研究的对象，旨在提高这一战略的可靠性和有效性。在此，我们将调查最近的研究领域的TCR基因转移处理这种方法的改进及其应用于治疗恶性，自身免疫性和感染性疾病。
T-cells are central players in the immune response against both pathogens and cancer. Their specificity is solely dictated by the T-cell receptor (TCR) they clonally express. As such, the genetic modification of T lymphocytes using pathogen- or cancer-specific TCRs represents an appealing strategy to generate a desired immune response from peripheral blood lymphocytes. Moreover, notable objective clinical responses were observed in terminally ill cancer patients treated with TCR-gene modified cells in several clinical trials conducted recently. Nevertheless, several key aspects of this approach are the object of intensive research aimed at improving the reliability and efficacy of this strategy. Herein, we will survey recent studies in the field of TCR-gene transfer dealing with the improvement of this approach and its application for the treatment of malignant, autoimmune, and infectious diseases.
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影响因子：
15.9
作者：
Berger, Carolina;Jensen, Michael C.;Riddell, Stanley R.
通讯作者：
Riddell, Stanley R.
DOI：
10.4049/jimmunol.1001775
发表时间：
2011-01-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Chinnasamy N;Wargo JA;Yu Z;Rao M;Frankel TL;Riley JP;Hong JJ;Parkhurst MR;Feldman SA;Schrump DS;Restifo NP;Robbins PF;Rosenberg SA;Morgan RA
通讯作者：
Morgan RA
影响因子：
6.4
作者：
Aarnoudse, CA;Krüse, M;Schrier, PI
通讯作者：
Schrier, PI
影响因子：
5.6
作者：
Chlewicki, LK;Holler, PD;Kranz, DM
通讯作者：
Kranz, DM
影响因子：
2.2
作者：
Birkholz, Katrin;Hofmann, Christian;Schaft, Niels
通讯作者：
Schaft, Niels