Effect of malarial infection on haematological parameters in population near Thailand-Myanmar border
Effect of malarial infection on haematological parameters in population near Thailand-Myanmar border
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DOI：
10.1186/1475-2875-13-218
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发表时间：
2014-06-05
期刊：
影响因子：
3
通讯作者：
Duangmano, Suwit
中科院分区：
文献类型：
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作者：
Kotepui, Manas;Phunphuech, Bhukdee;Duangmano, Suwit
背景：在泰国，疟疾是一个主要的蚊媒公共卫生问题，具有不同的血液学后果。该研究旨在阐明怀疑疟疾感染者的血液学变化及其对疟疾感染的可能预测价值。方法：对2009年期间在泰国疟疾地方性传播区Tak省Phop Phra医院收治的4，985名患者（包括703名疟疾感染者和4，282名非疟疾感染者）的血液学参数进行了评估。以下参数在疟疾感染患者中显著降低;红细胞（RBC）计数、血红蛋白（Hb）、血小板计数、白细胞（WBC）计数、中性粒细胞、单核细胞、淋巴细胞和嗜酸性粒细胞计数，而平均红细胞体积（MCV）、平均红细胞血红蛋白（MCH）、平均红细胞血红蛋白浓度（MCHC）、嗜中性粒细胞-淋巴细胞比率（NLR）、和单核细胞淋巴细胞比率（MLR）高于非疟疾感染患者。血小板计数<150，000/uL的患者感染疟疾的可能性高31.8倍（比值比）。84.9%的疟疾患者存在血小板减少，且与年龄、性别、民族无关（P <0.0001）。结论：疟疾患者的血液学指标均有明显改变，血小板、白细胞、淋巴细胞计数降低是疟疾感染的重要预测指标。当与其他临床和显微镜方法结合使用时，这些参数可以改善疟疾的诊断和治疗。
Background: Malaria is a major mosquito-borne public health problem in Thailand with varied haematological consequences. The study sought to elucidate the haematological changes in people who suspected malaria infection and their possible predictive values of malaria infection.Methods: Haematological parameters of 4,985 patients, including 703 malaria-infected and 4,282 non-malaria infected, who admitted at Phop Phra Hospital, Tak Province, an area of malaria endemic transmission in Thailand during 2009 were evaluated.Results: The following parameters were significantly lower in malaria-infected patients; red blood cells (RBCs) count, haemoglobin (Hb), platelets count, white blood cells (WBCs) count, neutrophil, monocyte, lymphocyte and eosinophil counts, while mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), Mean corpuscular haemoglobin concentration (MCHC), neutrophil-lymphocyte ratio (NLR), and monocyte-lymphocyte ratio (MLR) were higher in comparison to non-malaria infected patients. Patients with platelet counts < 150,000/uL were 31.8 times (odds ratio) more likely to have a malaria infection. Thrombocytopenia was present in 84.9% of malaria-infected patients and was independent of age, gender and nationality (P value < 0.0001).Conclusion: Patients infected with malaria exhibited important changes in most of haematological parameters with low platelet, WBCs, and lymphocyte counts being the most important predictors of malaria infection. When used in combination with other clinical and microscopy methods, these parameters could improve malaria diagnosis and treatment.