Effect of mineral-collagen interfacial behavior on the microdamage progression in bone using a probabilistic cohesive finite element model
Effect of mineral-collagen interfacial behavior on the microdamage progression in bone using a probabilistic cohesive finite element model
复制标题
使用概率内聚有限元模型研究矿物-胶原界面行为对骨微损伤进展的影响
DOI：
10.1016/j.jmbbm.2011.02.003
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发表时间：
2011-10-01
影响因子：
3.9
通讯作者：
Wang, Xiaodu
中科院分区：
文献类型：
--
作者：
Luo, Qing;Nakade, Rugved;Wang, Xiaodu
超微结构水平上矿物相和胶原相的相互作用对骨组织的力学性能起着重要的决定作用。本研究使用内聚区建模技术模拟了三种类型的矿物-胶原相互作用（即离子相互作用、氢/范德华键和打开/滑动模式下的范德华/粘性剪切）。考虑到骨的非均匀性，也采用概率失效分析方法来解释矿物-胶原界面行为对板层骨组织微损伤积累的影响。研究结果表明，不同的界面行为导致不同类型的微损伤积累。矿物相和胶原相之间的离子相互作用导致线性微裂纹的形成，而范德华/粘性剪切相互作用可能促进弥漫性损伤的形成。在氢键/范德华键的情况下，观察到骨中微损伤积累的过渡行为。本研究结果可能有助于了解矿物质-胶原蛋白相互作用的机制及其对骨破坏机制的影响。(C) 2011 Elsevier Ltd.版权所有。
The interactions between mineral and collagen phases in the ultrastructural level play an important role in determining the mechanical properties of bone tissue. Three types of mineral-collagen interaction (i.e., ionic interactions, hydrogen/van der Waals bonds, and van der Waals/viscous shear in opening/sliding mode, respectively) have been simulated in this study, using cohesive zone-modeling techniques. Considering the inhomogeneity of bone, a probabilistic failure analysis approach has been also employed to account for the effect of mineral-collagen interfacial behavior on microdamage accumulation in lamellar bone tissues. The results of this study suggested that different interfacial behaviors cause different types of microdamage accumulation. The ionic interactions between the mineral and collagen phases lead to the formation of linear microcracks, while the van der Waals/viscous shear interactions may facilitate the formation of diffuse damage. In the case of hydrogen/van der Waals bonds, a transitional behavior of microdamage accumulation in bone was observed. The findings of this study may help in understanding the mechanisms of mineral-collagen interactions and its effects on the failure mechanism of bone. (C) 2011 Elsevier Ltd. All rights reserved.