Risk of injury from alcohol, marijuana and emergency department patients
Risk of injury from alcohol, marijuana and emergency department patients
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DOI：
10.1016/j.drugalcdep.2017.01.019
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发表时间：
2017-05-01
影响因子：
4.2
通讯作者：
Brubacher, Jeffrey R.
中科院分区：
文献类型：
--
作者：
Cherpitel, Cheryl J.;Ye, Yu;Brubacher, Jeffrey R.
工作背景：众所周知，酒精与伤害有关，但很少有人知道酒精和其他药物对伤害的联合使用;特别是大麻，鉴于在美国和加拿大使用越来越合法化。方法：在温哥华的两个地点和维多利亚的一个地点的急诊科采访了18岁及以上患者的概率样本，BC（n = 1191例受伤患者和1613例非受伤患者）。病例对照和病例交叉分析被用来分析损伤的风险，根据自我报告的酒精和药物使用（大麻，兴奋剂，镇静剂）injure.Results：损伤的风险显着升高（p < 0.001）单独使用酒精在病例对照（OR= 2.72）和病例交叉分析（OR= 2.80），但不是任何的三种药物类。酒精与每类药物的相互作用进行了测试，并在病例对照分析中仅对大麻有轻微意义（OR= 4.42; p = 0.088）。在病例对照分析中，酒精与两种或多种药物的相互作用也很显著（OR= 0.03; p = 0.035）。受伤前饮酒的量对于那些在此期间也使用药物的人来说更大，并且与报告的药物数量呈正相关。鉴于病例对照和病例交叉研究设计都涉及潜在问题，不一致的发现表明，在得出任何关于酒精和大麻联合使用是否存在额外风险的明确结论时要谨慎，并且是未来研究的重要领域。(C)2017爱思唯尔B. V.保留所有权利。
Background: Alcohol is known to be associated with injury, but little is known of combined use of alcohol and other drugs on injury; especially important for marijuana, given increasing legalization of use in the U.S. and Canada.Methods: Probability samples of patients 18 and older were interviewed in the emergency department at two sites in Vancouver and one in Victoria, BC (n = 1191 injured and 1613 non-injured patients). Case control and case-crossover analyses were used to analyze risk of injury, based on self-reported alcohol and drug use (marijuana, stimulants, depressants) prior to injury.Results: Risk of injury was significantly elevated (p < 0.001) for alcohol use alone in both case-control (OR= 2.72) and case-crossover analyses (OR= 2.80) but not for any of the three drug classes. The interaction of alcohol with each class of drug was tested, and marginally significant only for marijuana in case-control analysis (OR= 4.42; p = 0.088). The interaction of alcohol and two or more drugs was also significant in case-control analysis (OR= 03; p = 0.035). The volume of alcohol consumed prior to injury was greater for those also using drugs during this time and positively associated with the number of drugs reported.Conclusion: Given the potential issues involved with both case-control and case-crossover study designs, the inconsistent findings suggest caution in reaching any definite conclusion regarding whether there is extra risk related to combined use of alcohol and marijuana, and is an important area for future research. (C) 2017 Elsevier B.V. All rights reserved.