Nanostructural drug-inorganic clay composites: Structure, thermal property and in vitro release of captopril-intercalated Mg–Al-layered double hydroxides
Nanostructural drug-inorganic clay composites: Structure, thermal property and in vitro release of captopril-intercalated Mg–Al-layered double hydroxides
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DOI：
10.1016/j.jssc.2006.03.019
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发表时间：
2006-06
影响因子：
3.3
通讯作者：
Hui Zhang;Kang-Yu Zou;Shaohua Guo;X. Duan
中科院分区：
文献类型：
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作者：
Hui Zhang;Kang-Yu Zou;Shaohua Guo;X. Duan
通过共沉淀法组装了一种纳米结构药物-无机粘土复合材料，其中包含药物活性化合物卡托普利（Cpl）插层的镁铝层状双氢氧化物（Cpl-LDHs），Mg/Al摩尔比为2.06。粉末 X 射线衍射 (XRD)、傅里叶变换红外光谱 (FT-IR) 和拉曼光谱分析表明 Cpl 成功插入层间，且含有 Cpl 二硫化物的 S-S 键垂直取向。 SEM 照片表明，合成的 Cpl-LDH 具有致密、无孔的结构，具有约 100 微米左右且相连的椭圆形颗粒。 50纳米。 TG-DTA 分析表明，与插层前的纯形式相比，由于涉及氢键的主客体相互作用，插层有机物质的热稳定性大大增强。体外释放研究表明，随着pH值从4.60增加到7.45，释放速率和释放百分比均显着降低，这是由于释放过程中释放机制可能发生变化。释放数据的动力学模拟以及从释放介质回收的样品的 XRD 和 FT-IR 分析表明，溶解机制主要负责 Cpl-LDH 在 pH 4.60 下的释放行为，而离子交换机制则负责 pH 7.45 下的释放行为。
A nanostructural drug-inorganic clay composite involving a pharmaceutically active compound captopril (Cpl) intercalated Mg–Al-layered double hydroxides (Cpl-LDHs) with Mg/Al molar ratio of 2.06 has been assembled by coprecipitation method. Powder X-ray diffraction (XRD), Fourier transform infrared spectra (FT-IR) and Raman spectra analysis indicate a successful intercalation of Cpl between the layers with a vertical orientation of Cpl disulphide-containing S–S linkage. SEM photo indicates that as-synthesized Cpl-LDHs possess compact and non-porous structure with approximately and linked elliptical shape particles of ca. 50nm. TG-DTA analyses suggest that the thermal stability of intercalated organic species is largely enhanced due to host–guest interaction involving the hydrogen bond compared to pure form before intercalation. The in vitro release studies show that both the release rate and release percentages markedly decrease with increasing pH from 4.60 to 7.45 due to possible change of release mechanism during the release process. The kinetic simulation for the release data, and XRD and FT-IR analyses for samples recovered from release media indicate that the dissolution mechanism is mainly responsible for the release behaviour of Cpl-LDHs at pH 4.60, while the ion-exchange one is responsible for that at pH 7.45.