Urokinase expression during the epithelial-mesenchymal transformation of the avian somite.
Urokinase expression during the epithelial-mesenchymal transformation of the avian somite.
复制标题
鸟类体节上皮间质转化过程中尿激酶的表达。
DOI：
10.1002/aja.1001940304
复制
发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Alexander,SM
中科院分区：
文献类型：
--
作者：
McGuire,PG;Alexander,SM
中轴骨骼形态发生的早期事件涉及体节的上皮-间质转化。体节腹内侧壁的细胞（硬节）迁移到脊索和神经管周围的区域，并凝聚形成椎骨的软骨模型。尿激酶活性在鹌鹑胚胎躯干的轴向区域被发现在这些阶段增加。原位杂交定位尿激酶mRNA表达在这一地区，并提出了一个重要的作用，这种蛋白酶在细胞迁移和基质重塑过程中的发展过程中的中轴骨骼。© 1992 Wiley利斯公司
Early events in the morphogenesis of the axial skeleton involve an epithelial‐mesenchymal transformation of the somites. Cells of the ventromedial wall of the somite (the sclerotome) migrate to regions surrounding the notochord and neural tube and condense to form the cartilage model of the vertebrae. Urokinase activity in the axial region of the quail embryo trunk was found to increase during these stages. In situ hybridization localized urokinase mRNA expression in this region and suggests an important role for this protease in the process of cell migration and matrix remodeling during development of the axial skeleton. © 1992 Wiley‐Liss, Inc.