Immunomodulatory effects of probiotics in the intestinal tract.
Immunomodulatory effects of probiotics in the intestinal tract.
复制标题
DOI：
10.21775/cimb.010.037
复制
发表时间：
2008
影响因子：
3.1
通讯作者：
V. Delcenserie;D. Martel;M. Lamoureux;J. Amiot;Y. Boutin;Debarati Roy
中科院分区：
文献类型：
--
作者：
V. Delcenserie;D. Martel;M. Lamoureux;J. Amiot;Y. Boutin;Debarati Roy
肠道微生物群是微生物刺激的最大来源，对人类健康产生有害和有益的影响。益生菌和肠上皮细胞之间的相互作用是免疫调节的起始事件，值得特别关注。益生菌的作用是菌株依赖性的，并且对于每种新的益生菌菌株，应该系统地建立与菌株接触的淋巴细胞、肠细胞或树突状细胞分泌的细胞因子谱。为了评估益生菌对免疫系统的影响，应尽可能首选模拟粘膜的模型，从而模拟生理现实。然后，应通过适当进行的随机双约束临床研究来支持体外观察到的效果。需要更详细的研究来确定益生菌对粘膜和全身免疫的确切作用模式。
The intestinal microbiota is the largest source of microbial stimulation that exerts both harmful and beneficial effects on human health. The interaction between probiotic and enterocytes is the initiating event in immunomodulation and merits particular attention. The effects of probiotic is strain dependent and for each new probiotic strain, profiles of cytokines secreted by lymphocytes, enterocytes or dendritic cells that come in contact with the strain should be systematically established. To evaluate the effects of probiotics on the immune system, models that mimic the mucosa, and thus the physiological reality, should be preferred whenever it is possible. Then, the in vitro observed effects should be backed up by properly conducted randomized double bind clinical studies. More detailed studies are needed to determine the precise action mode of probiotics on both mucosal and systemic immunity.