The inositol 1,4,5-trisphosphate receptor (Itpr) gene family in Xenopus: identification of type 2 and type 3 inositol 1,4,5-trisphosphate receptor subtypes.
The inositol 1,4,5-trisphosphate receptor (Itpr) gene family in Xenopus: identification of type 2 and type 3 inositol 1,4,5-trisphosphate receptor subtypes.
复制标题
非洲爪蟾肌醇 1,4,5-三磷酸受体 (Itpr) 基因家族：2 型和 3 型肌醇 1,4,5-三磷酸受体亚型的鉴定。
DOI：
10.1042/bj20070101
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Marchant,JonathanS
中科院分区：
文献类型：
--
作者：
Zhang,Dan;Boulware,MichaelJ;Pendleton,MatthewR;Nogi,Taisaku;Marchant,JonathanS
Studies in theXenopusmodel system have provided considerable insight into the developmental role of intracellular Ca2+signals produced by activation of IP3Rs (inositol 1,4,5-trisphosphate receptors). However, unlike mammalian systems where three IP3R subtypes have been well characterized, our molecular understanding of the IP3Rs that underpin Ca2+signalling duringXenopusembryogenesis relate solely to the original characterization of the ‘XenopusIP3R’ cloned and purified fromXenopus laevisoocytes several years ago. In the present study, we have identifiedXenopustype 2 and type 3 IP3Rs and report the full-length sequence, genomic architecture and developmental expression profile of these additional IP3R subtypes. In the light of the emerging genomic resources and opportunities for genetic manipulation in the diploid frogXenopus tropicalis, these data will facilitate manipulations to resolve the contribution of IP3R diversity in Ca2+signalling events observed during vertebrate development.
