Nitric-Oxide-Releasing aza-BODIPY: A New Near-Infrared J-Aggregate with Multiple Antibacterial Modalities
Nitric-Oxide-Releasing aza-BODIPY: A New Near-Infrared J-Aggregate with Multiple Antibacterial Modalities
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DOI：
10.1002/anie.202207250
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发表时间：
2022-06-23
影响因子：
16.6
通讯作者：
Hu, Jinming
中科院分区：
文献类型：
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作者：
Bao, Xinyao;Zheng, Shaoqiu;Hu, Jinming
近红外J-聚集体的发展因其广泛的应用而受到越来越多的关注。在这里，我们报道了一个含胺的氮杂-BODIPY前体(BDP-NH2)的亚硝化反应，得到了第一个释放一氧化氮(NO)的近红外J-聚集体(BDP-NO)。N-亚硝胺的引入有效地抑制了BDP-NH2的芳香族相互作用，促进了胶束纳米粒子中J-聚集体的形成，并使近红外窗口(820 Nm)发生了约109 nm的显著红移。有趣的是，NO的释放和光热转化效率(PTCE)可以通过胶束纳米颗粒中BDP-NO的负载含量来微妙地调节，从而通过探索NO释放、光热疗法(PTT)或两者兼而有之来实现多种抗菌方式。我们证明，在体内治疗MRSA感染时，联合使用NO和PTT可以提高抗菌活性，同时减轻PTT相关的炎症。
The development of near-infrared (NIR) J-aggregates has received increasing attention due to their broad applications. Here, we report the nitrosation of an amine-containing aza-BODIPY precursor (BDP-NH2), affording the first nitric oxide (NO)-releasing NIR J-aggregate (BDP-NO). The introduction of N-nitrosamine moieties efficiently inhibits the aromatic interactions of BDP-NH2, which instead promotes the formation of J-aggregates within micellar nanoparticles with a remarkable bathochromic shift of approximate to 109 nm to the NIR window (820 nm). Interestingly, the NO release and photothermal conversion efficiency (PTCE) can be delicately tuned by the loading contents of BDP-NO within micellar nanoparticles, thereby enabling multiple antibacterial modalities by exploring either NO release, photothermal therapy (PTT), or both. We demonstrate the combination of NO and PTT can elevate antibacterial activity while attenuating PTT-associated inflammation for the in vivo treatment of MRSA infection.