Dopamine mediates context-dependent modulation of sensory plasticity in C-elegans
Dopamine mediates context-dependent modulation of sensory plasticity in C-elegans
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DOI：
10.1016/j.neuron.2007.07.023
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发表时间：
2007-08-16
期刊：
影响因子：
16.2
通讯作者：
Schafer, William R.
中科院分区：
文献类型：
--
作者：
Kindt, Katie S.;Quast, Kathleen B.;Schafer, William R.
多巴胺与多种形式的行为可塑性的调节有关，包括食欲学习和成瘾。一个重要的挑战是了解多巴胺在细胞水平上的作用如何改变神经回路的特性以改变行为。线虫C.在秀丽隐杆线虫中，多巴胺调节由身体接触触发的逃避反射的习惯化。在没有食物的情况下，动物比在有食物的情况下更快地适应;这种关于食物可获得性的背景信息是由感觉细菌存在的多巴胺能机械感觉神经元提供的。我们发现，多巴胺通过选择性地调节前体机械感受器的触觉反应来改变习惯动力学;这种调节涉及D1样多巴胺受体、Gq/PLC-β信号通路和触觉神经元内的钙释放。有趣的是，身体接触机械感受器本身可以激发多巴胺神经元，形成一个正反馈回路，能够整合背景和经验来调节机械感觉注意力。
Dopamine has been implicated in the modulation of diverse forms of behavioral plasticity, including appetitive learning and addiction. An important challenge is to understand how dopamine's effects at the cellular level alter the properties of neural circuits to modify behavior. In the nematode C. elegans, dopamine modulates habituation of an escape reflex triggered by body touch. In the absence of food, animals habituate more rapidly than in the presence of food; this contextual information about food availability is provided by dopaminergic mechanosensory neurons that sense the presence of bacteria. We find that dopamine alters habituation kinetics by selectively modulating the touch responses of the anterior-body mechanoreceptors; this modulation involves a D1-like dopamine receptor, a Gq/PLC-beta signaling pathway, and calcium release within the touch neurons. Interestingly, the body touch mechanoreceptors can themselves excite the dopamine neurons, forming a positive feedback loop capable of integrating context and experience to modulate mechanosensory attention.