Adrenal hormone response and psychophysiological correlates under psychosocial stress in individuals with irritable bowel syndrome
Adrenal hormone response and psychophysiological correlates under psychosocial stress in individuals with irritable bowel syndrome
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DOI：
10.1016/j.ijpsycho.2012.01.006
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发表时间：
2012-04-01
影响因子：
3
通讯作者：
Shimada, Hironori
中科院分区：
文献类型：
--
作者：
Sugaya, Nagisa;Izawa, Shuhei;Shimada, Hironori
目的：在这项研究中，我们调查了肾上腺激素的水平和相对比例，（包括皮质醇、脱氢表雄酮[DHEA]和硫酸脱氢表雄酮[DHEA-S]）及其在肠易激综合征（IBS）患者急性心理社会应激下的心理生理相关因素。方法：53名大学生参与了这项研究其中IBS患者13例（IBS组），非IBS患者40例（对照组）。参与者暴露于标准化的实验室压力源，其中包括发表演讲和执行心算任务。结果：IBS组DHEA-S水平及DHEA-S/DHEA比值均显著低于对照组，而皮质醇/DHEA-S比值在整个实验过程中均显著高于对照组。在IBS组中，对威胁的评估与皮质醇水平呈正相关（r = 0.61），对可控性的评估与皮质醇水平（r = -0.64）和皮质醇/DHEA比率（r = -0.71）呈负相关。结论：IBS患者DHEA-S水平较低，其应激性认知评价在急性心理社会应激下以皮质醇为主。这种肾上腺激素反应可能参与IBS患者腹部症状的加重。(C)2012爱思唯尔有限公司版权所有。
Objective: In this study, we investigated levels and relative ratios of adrenal hormones (including cortisol, dehydroepiandrosterone [DHEA], and DHEA-sulfate [DHEA-S]) and their psychophysiological correlates under acute psychosocial stress in individuals with irritable bowel syndrome (IBS).Methods: Fifty-three college students participated in the study (male: 42, female: 11; mean age: 22.64 years), including 13 individuals with IBS (IBS group) and 40 individuals without IBS (control group). The participants were exposed to a standardized laboratory stressor, which included delivering a speech and performing a mental arithmetic task. We measured subjective stress levels and salivary cortisol, DHEA, and DHEA-S levels at relevant time points before, during, and after the tasks.Results: DHEA-S level and the DHEA-S/DHEA ratio in the IBS group were significantly lower than those in the control group, and the cortisol/DHEA-S ratio in the IBS group was higher than that in the control group throughout the experiment. In the IBS group, the appraisal of a threat was positively correlated with cortisol levels (r = 0.61), and the appraisal of controllability was negatively correlated with cortisol levels (r = -0.64) and with the cortisol/DHEA ratio (r = -0.71). The control group showed a significant positive correlation between the appraisal of threat and cortisol levels (r = 0.32).Conclusion: The present study indicates that individuals with IBS had lower DHEA-S levels, and that their stressful cognitive appraisals under acute psychosocial stress caused the effects of cortisol to dominate. This adrenal hormone response may be involved in exacerbating abdominal symptoms in individuals with IBS. (C) 2012 Elsevier B.V. All rights reserved.