Autoantibodies directed against domain I of beta2-glycoprotein I.
Autoantibodies directed against domain I of beta2-glycoprotein I.
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DOI：
10.1007/s11926-010-0144-8
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发表时间：
2011-02
影响因子：
5
通讯作者：
de Groot, Philip G.
中科院分区：
文献类型：
--
作者：
de Laat, Bas;de Groot, Philip G.
诊断为抗磷脂综合征的患者通常患有血管血栓形成、妊娠发病率或两者的组合。由于这些临床症状的高患病率，抗磷脂综合征的诊断几乎完全依赖于患者血浆中抗磷脂抗体的检测。然而，并不是每一个人与抗磷脂抗体在他或她的血浆患有血栓形成和/或妊娠发病率，这表明存在不同群体的抗磷脂抗体。尽管已鉴定出许多与抗磷脂综合征相关的抗原，但β2-糖蛋白I被认为是临床上最重要的抗原。在过去的十年中，越来越多的证据表明β2-糖蛋白I的第一个结构域上存在一个优势表位。几项研究已经检测到识别结构域I上的隐蔽表位的特定抗体群体，所述表位至少包含精氨酸39至精氨酸43。与识别β2-糖蛋白I的其他结构域的抗体相反，发现抗结构域I抗体与临床症状高度相关。这篇综述讨论了几项研究，主要是诊断水平上的抗磷脂综合征内的域I的作用进行了调查。
Patients diagnosed with the antiphospholipid syndrome typically suffer from vascular thrombosis, pregnancy morbidity, or a combination of the two. Due to the high prevalence of these clinical symptoms, the diagnosis of antiphospholipid syndrome is almost completely dependent on the detection of antiphospholipid antibodies in patient plasma. However, not every individual with antiphospholipid antibodies in his or her plasma suffers from thrombosis and/or pregnancy morbidity, which suggests the existence of different populations of antiphospholipid antibodies. Although many antigens have been identified in relation to the antiphospholipid syndrome, β2-glycoprotein I is regarded as clinically most significant. During the past decade, evidence has accumulated to suggest the presence of a dominant epitope on the first domain of β2-glycoprotein I. Several studies have detected a specific population of antibodies recognizing a cryptic epitope on domain I, at least comprising arginine 39 to arginine 43. In contrast to antibodies recognizing other domains of β2-glycoprotein I, anti-domain I antibodies are found to be highly associated with clinical symptoms. This review discusses several studies that have investigated a role for domain I within the antiphospholipid syndrome on a predominantly diagnostic level.
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影响因子：
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作者：
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通讯作者：
Shoenfeld, Y
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