Cancer-associated fibroblasts as another polarized cell type of the tumor microenvironment.
Cancer-associated fibroblasts as another polarized cell type of the tumor microenvironment.
复制标题
DOI：
10.3389/fonc.2014.00062
复制
发表时间：
2014
影响因子：
4.7
通讯作者：
Augsten M
中科院分区：
文献类型：
--
作者：
Augsten M
肿瘤或癌症相关成纤维细胞（CAFs）是不同癌症中最丰富的基质细胞类型之一，并构成异质细胞群。传统上，CAFs被赋予促肿瘤作用，刺激肿瘤生长和进展。最近的研究也证明了CAFs的肿瘤抑制作用，表明肿瘤驻留的成纤维细胞表现出与其他基质细胞类型相似程度的可塑性。与肿瘤环境和不同来源的相互作用是CAF异质性的两个重要因素。这篇综述强调了我们对CAF生物学理解的最新进展，并提出将细胞“极化”这一术语扩展到CAF上，以反映其表型多样性，该术语先前用于描述各种免疫细胞的不同激活状态。
Tumor- or cancer-associated fibroblasts (CAFs) are one of the most abundant stromal cell types in different carcinomas and comprise a heterogeneous cell population. Classically, CAFs are assigned with pro-tumorigenic effects stimulating tumor growth and progression. More recent studies demonstrated also tumor-inhibitory effects of CAFs suggesting that tumor-residing fibroblasts exhibit a similar degree of plasticity as other stromal cell types. Reciprocal interactions with the tumor milieu and different sources of origin are emerging as two important factors underlying CAF heterogeneity. This review highlights recent advances in our understanding of CAF biology and proposes to expand the term of cellular “polarization,” previously introduced to describe different activation states of various immune cells, onto CAFs to reflect their phenotypic diversity.