Mitochondrial dysfunction and serum lactate as a biomarker for the progression and disability in MS and its correlation with the radiological findings
Mitochondrial dysfunction and serum lactate as a biomarker for the progression and disability in MS and its correlation with the radiological findings
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DOI：
10.1080/01616412.2021.1893567
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发表时间：
2021-03-05
影响因子：
1.9
通讯作者：
Eltoukhy，Khaled
中科院分区：
文献类型：
--
作者：
Esmael，Ahmed;Talaat，Mona;Eltoukhy，Khaled
目的：目的：研究多发性硬化（MS）患者血清乳酸水平，探讨血清乳酸水平与MS病情进展及致残的关系，以及线粒体功能障碍在MS发病中的重要作用。方法：采用病例对照研究方法，共纳入MS患者50例，健康对照30例。对所有患者进行详细的病史采集、完整的神经系统检查和使用扩展残疾状态量表（EDSS）对残疾进行临床评估。结果：MS患者的血清乳酸水平（22.87 ± 5.92mg/dl）比健康对照组（6.39 ± 0.96.39 ± 0.91）高3.5倍（P < 0.001）。重要的是，与RR病程的MS病例相比，进行性病程的MS病例的血清乳酸值升高。血清乳酸水平与MS病程（r = 0.342，P = 0.015）、复发次数（r = 0.335，P = 0.022）和EDSS评分（r = 0.483，P < 0.001）呈直线相关。此外，血清乳酸与脂质/乳酸之间存在强正相关（r = 0.461，P = 0.001），室周病变相关系数r = 0.453，P = 0.005，血乳酸与脑皮质损害呈中度正相关结论：血清乳酸的测定对MS的诊断有一定的帮助，并支持线粒体功能障碍和轴索损伤在MS中起重要作用的假设。临床试验研究注册：ClinicalTrials.gov ID：NCT 04210960
Objective: To study the serum lactate level in MS and to explore its correlation with the progression and disability in multiple sclerosis (MS), and the important role of mitochondrial dysfunction in the pathogenesis of MS.Methods: This case-control study included 80 participants, involved 50 MS patients and 30 normal healthy controls. Detailed history taking, complete neurological examination, and clinical evaluation of the disability using the Expanded Disability Status Scale (EDSS) were done for all patients. Level of serum lactate was measured in both groups and was correlated with EDSS, MS subtypes, MRI brain, and MRS findings.Results: Serum lactate in MS patients was about three and half times higher than serum lactate levels of healthy controls (22.87 ± 5.92 mg/dl versus 6.39 ± 0.9 6.39 ± 0.91, p < 0.001). Importantly, serum lactate values were increased in MS cases with a progressive course compared with MS cases with RR course. Also, there were linearly correlations linking serum lactate levels and the duration of MS (r = 0.342, P = 0.015), relapses numbers (r = 0.335, P = 0.022), and EDSS (r = 0.483, P < 0.001). Also, there were strong positive correlations between serum lactate and Lipid/Lactate (r = 0.461, P = 0.001), periventricular lesion (r = 0.453, P = 0.005), and moderate positive correlations between serum lactate and juxtacortical lesion (r = 0.351, P = 0.02), and infratentorial lesion (r = 0.355, P = 0.02).Conclusion: Measurement of serum lactate may be helpful in MS and this supports the hypothesis of the critical role of mitochondrial dysfunction and axonal damage in MS.Registration of Clinical Trial Research: ClinicalTrials.gov ID: NCT04210960