Androgen Receptor-Related Non-coding RNAs in Prostate Cancer.
Androgen Receptor-Related Non-coding RNAs in Prostate Cancer.
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DOI：
10.3389/fcell.2021.660853
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发表时间：
2021
影响因子：
5.5
通讯作者：
Cao Q
中科院分区：
文献类型：
--
作者：
Yang Y;Liu KY;Liu Q;Cao Q
前列腺癌（PCa）是美国男性癌症相关死亡的第二大原因。雄激素受体（AR）信号通路是前列腺癌的主要致癌途径，控制AR活性是治疗前列腺癌的主要策略。大量患者由于AR异常激活而对雄激素剥夺治疗（ADT）产生耐药性，导致去势抵抗性前列腺癌（CRPC）的发生。了解前列腺癌中AR信号的分子机制对于确定前列腺癌患者的新治疗靶点至关重要。高通量RNA测序（RNA-seq）技术的最新进展发现，越来越多的非编码RNA （ncrna）通过各种机制在不同疾病中发挥关键作用。一些ncrna已显示出作为生物标志物和治疗靶点的巨大潜力。许多ncrna已被研究通过与AR直接关联来调节PCa。在这篇综述中，我们旨在全面总结AR相关ncrna在PCa进展中作为AR调节剂或靶点的功能作用和分子机制的最新发现。
Prostate cancer (PCa) is the second leading cause of cancer-related death among men in the United States. Androgen receptor (AR) signaling is the dominant oncogenic pathway in PCa and the main strategy of PCa treatment is to control the AR activity. A large number of patients acquire resistance to Androgen deprivation therapy (ADT) due to AR aberrant activation, resulting in castration-resistant prostate cancer (CRPC). Understanding the molecular mechanisms underlying AR signaling in the PCa is critical to identify new therapeutic targets for PCa patients. The recent advances in high-throughput RNA sequencing (RNA-seq) techniques identified an increasing number of non-coding RNAs (ncRNAs) that play critical roles through various mechanisms in different diseases. Some ncRNAs have shown great potentials as biomarkers and therapeutic targets. Many ncRNAs have been investigated to regulate PCa through direct association with AR. In this review, we aim to comprehensively summarize recent findings of the functional roles and molecular mechanisms of AR-related ncRNAs as AR regulators or targets in the progression of PCa.
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