Monoalkylglycerol ether lipids promote adipogenesis.
Monoalkylglycerol ether lipids promote adipogenesis.
复制标题
DOI：
10.1021/ja111173c
复制
发表时间：
2011-04-13
影响因子：
15
通讯作者：
Saghatelian A
中科院分区：
文献类型：
--
作者：
Homan EA;Kim YG;Cardia JP;Saghatelian A
导致脂肪组织产生（脂肪形成）的分子机制具有基础和生物医学意义。脂肪形成的细胞模型在定义调节脂肪形成的生物分子（主要是基因和蛋白质）方面被证明是非常有价值的。在这里，使用非靶向代谢组学方法的分化脂肪细胞的分析导致发现单烷基甘油醚（MAGE）作为脂肪细胞分化因子的天然类别。
The molecular mechanisms that lead to the generation of adipose tissue (adipogenesis) are of basic and biomedical interest. Cellular models of adipogenesis have proven extremely valuable in defining biomolecules—primarily genes and proteins—that regulate adipogenesis. Here, the analysis of differentiating adipocytes using an untargeted metabolomics approach led to the discovery of the monoalkylglycerol ethers (MAGEs) as a natural class of adipocyte differentiation factors.