On-chip biomedical imaging.
On-chip biomedical imaging.
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DOI：
10.1109/rbme.2012.2215847
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发表时间：
2013
影响因子：
17.6
通讯作者：
Ozcan A
中科院分区：
文献类型：
--
作者：
Göröcs Z;Ozcan A
芯片实验室系统迅速兴起，为超紧凑、高效、可大规模生产且具有成本效益的生物医学研究和诊断工具铺平了道路。尽管这类微流体和微机电系统实现了高度集成，并且能够在同一芯片上执行各种重要任务，比如细胞培养、分选和染色，但它们的成像需求仍然依赖于传统显微镜。最近，几种替代性的芯片上光学成像技术已经被引入，它们有可能在各种芯片实验室应用中替代传统显微镜。在此，我们对这些新近出现的芯片上生物医学成像模式进行批判性综述，包括接触式阴影成像、无透镜全息显微镜、芯片上荧光显微镜以及无透镜光学断层扫描。
Lab-on-a-chip systems have been rapidly emerging to pave the way toward ultra-compact, efficient, mass producible and cost-effective biomedical research and diagnostic tools. Although such microfluidic and micro electromechanical systems achieved high levels of integration, and are capable of performing various important tasks on the same chip, such as cell culturing, sorting and staining, they still rely on conventional microscopes for their imaging needs. Recently several alternative on-chip optical imaging techniques have been introduced, which have the potential to substitute conventional microscopes for various lab-on-a-chip applications. Here we present a critical review of these recently emerging on-chip biomedical imaging modalities, including contact shadow imaging, lensfree holographic microscopy, fluorescent on-chip microscopy and lensfree optical tomography.