Foster children's diurnal production of cortisol: An exploratory study
Foster children's diurnal production of cortisol: An exploratory study
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DOI：
10.1177/1077559505285779
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发表时间：
2006-05-01
影响因子：
5.1
通讯作者：
Levine, S
中科院分区：
文献类型：
--
作者：
Dozier, M;Manni, M;Levine, S
寄养的幼儿往往经历早期照料不足和与照料者分离的情况。临床前研究表明，早期护理不足和分离与下丘脑-垂体-肾上腺（HPA）轴调节的长期变化有关。在这项研究中，研究人员对55名被寄养儿童和104名未被寄养儿童的皮质醇产生的白天模式进行了研究。唾液样本在2天内在起床，下午和就寝时采集。计算一天中每个时间的平均唾液皮质醇值。一组（寄养与对照）X时间（上午，下午，晚上）的互动出现，反映了较少的下降水平在一天中寄养比对照儿童。白天的模式分为典型，低，或高。被寄养的儿童比没有被寄养的儿童有更高的非典型皮质醇产生模式的发生率。这些差异表明，与寄养相关的条件干扰儿童的能力，以调节神经内分泌功能。
Young children in foster care have often experienced inadequate early care and separations from caregivers. Preclinical studies suggest that early inadequate care and separations are associated with long-term changes in regulation of the hypothalamic-pituitary-adrenal (HPA) axis. In this study, the daytime pattern of cortisol production was examined among 55 young children who had been placed into foster care and 104 children who had not. Saliva samples were taken at wake-up, in the afternoon, and bedtime for 2 days. Average salivary cortisol values for each time of day were computed. A group (foster vs. comparison) X time (morning, afternoon, night) interaction emerged, reflecting less decline in levels across the day for foster than comparison children. Daytime patterns were categorized as typical, low, or high. Children who had been in foster care had higher incidences of atypical Patterns of cortisol production than children who had not. These differences suggest that conditions associated with foster care interfere with children's ability to regulate neuroendocrine functioning.