Intragastric intubation of alcohol during the perinatal period.
Intragastric intubation of alcohol during the perinatal period.
复制标题
围产期胃插管酒精。
DOI：
10.1007/978-1-59745-242-7_8
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Lawrence,CharlesR
中科院分区：
文献类型：
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作者：
Kelly,SandraJ;Lawrence,CharlesR
胎儿酒精谱系障碍 (FASD) 动物模型有助于分离酒精作为致畸剂并展示行为和神经影响。对于啮齿动物有许多不同的模型，它们具有不同的优点和缺点。这里描述了 FASD 的三个月模型；该模型使用怀孕母鼠和幼崽的胃插管来模拟人类所有三个三个月的酒精暴露情况。该模型没有使用昂贵的设备，并且相对容易实现。该模型可以很好地控制酒精剂量并采用口服给药途径。这里使用的剂量没有营养不良的影响。该模型的一个缺点是插管过程的压力，并讨论了最小化这种压力的方法。此外，还描述了测量血液酒精水平的方法。
Animal models of fetal alcohol spectrum disorder (FASD) have been instrumental in isolating alcohol as a teratogen and demonstrating behavioral and neural effects. There are a number of different models for rodents with various strengths and weaknesses. A three-trimester model of FASD is described here; the model uses intragastric intubation of both pregnant dams and pups to mimic alcohol exposure across all three trimesters in humans. The model does not use expensive equipment and is relatively easy to accomplish. The model allows excellent control of alcohol dose and uses an oral route of administration. There are no undernutrition effects with the doses used here. A drawback of the model is the stress of the intubation procedures and ways in which to minimize this stress are discussed. In addition, a method to measure blood alcohol levels is described.