Dendritic cells, antibodies reactive with oxLDL, and inflammation.
Dendritic cells, antibodies reactive with oxLDL, and inflammation.
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树突状细胞、与 oxLDL 反应的抗体和炎症。
DOI：
10.1177/0022034511407338
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发表时间：
2012
影响因子：
7.6
通讯作者：
Schenkein,HA
中科院分区：
文献类型：
--
作者：
Tew,JG;ElShikh,ME;ElSayed,RM;Schenkein,HA
牙周炎似乎促进慢性炎症性疾病，包括动脉粥样硬化，但相关机制需要澄清。牙龈卟啉单胞菌（Porphyromonas gingivalis）和放线菌聚集菌（Aggregatibacteractinomycetemcomitem）均能诱导特异性的IgG应答，其中IgG2主要由IFN-γ介导，并受树突状细胞（DCs）的促进。疟原虫诱导的低密度脂蛋白反应性抗体。牙龈炎和A.放线菌伴抗蛋白包括抗磷酸胆碱（α-PC）和β 2-糖蛋白-1依赖性抗心磷脂（α-CL），这些抗体可能在机制水平上与慢性炎症性疾病相联系。抗体介导的oxLDL或细菌摄取显著增强DC-IL-12，DC-IL-12诱导NK细胞-IFN-γ应答，其促进Th-1应答和持续炎症。DC可能来源于单核细胞，这在侵袭性牙周炎（AgP）单核细胞的培养物中是惊人的，其中DC数量约为对照水平的两倍。此外，AgP患者的血清α-CL水平经常升高，这些抗体促进抗磷脂综合征患者的动脉粥样硬化。血清可溶性细胞间粘附分子、可溶性血管细胞粘附分子和可溶性E-选择素水平升高是动脉粥样硬化相关的血管炎症指标，这些标志物在高α-CL的AgP患者亚组中升高。我们的理由是牙周炎患者与oxLDL反应的抗体升高可能是一个亚组在高风险的心血管后遗症。
Periodontitis appears to promote chronic inflammatory diseases, including atherosclerosis, but relevant mechanisms need clarification. Oral bacteria induce antibodies that bind not only bacteria, but also oxLDL.Porphyromonas gingivalisandAggregatibacter actinomycetemcomitansinduce remarkable IgG responses that are dominated by IgG2, and IgG2 is IFN-γ-dependent and is promoted by dendritic cells (DCs). LDL-reactive antibodies induced byP. gingivalisandA. actinomycetemcomitansinclude anti-phosphorylcholine (α-PC) and β2-glycoprotein-1-dependent anticardiolipin (α-CL), and these antibodies may link chronic inflammatory diseases at a mechanistic level. Antibody-mediated uptake of oxLDL or bacteria dramatically enhances DC-IL-12, and DC-IL-12 induces NK-cell-IFN-γ responses that promote Th-1 responses and sustained inflammation. DCs may be derived from monocytes, and this is striking in cultures of aggressive periodontitis (AgP) monocytes, where DC numbers are about double control levels. Moreover, serum α-CL levels in individuals with AgP are frequently elevated, and these antibodies promote atherosclerosis in persons with antiphospholipid syndrome. Elevated serum levels of soluble-intercellular adhesion molecule, soluble-vascular cell adhesion molecule, and soluble-E-selectin are atherosclerosis-associated indicators of vascular inflammation, and these markers are elevated in the subset of AgP patients with high α-CL. We reason that periodontitis patients with elevated antibodies reactive with oxLDL could be a subgroup at high risk for cardiovascular sequelae.