Stenosis-dependent role of nitric oxide and prostaglandins in chronic renal ischemia.
Stenosis-dependent role of nitric oxide and prostaglandins in chronic renal ischemia.
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一氧化氮和前列腺素在慢性肾缺血中的狭窄依赖性作用。
DOI：
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
T. Saruta
中科院分区：
文献类型：
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作者：
H. Tokuyama;K. Hayashi;H. Matsuda;E. Kubota;M. Honda;K. Okubo;Y. Ozawa;T. Saruta
在单侧肾动脉狭窄的夹闭和非夹闭肾脏中，研究了一氧化氮（NO）和洋地黄素（PG）在改善肾脏血流动力学中的作用。采用夹闭犬左肾动脉4周的方法建立慢性单侧肾缺血模型，用微透析技术测定肾间质硝酸盐和亚硝酸盐及前列腺素E2（PGE 2）含量。单侧肾动脉狭窄导致中度和重度夹闭肾脏的肾血浆流量（RPF）下降45 +/- 1和73 +/- 1%，而重度狭窄的非夹闭肾脏的RPF下降21 +/- 3%。中度（-31 +/-1%）和重度（-63 +/-4%）切除肾脏的肾脏硝酸盐+亚硝酸盐降低。N（ω）-硝基-L-精氨酸甲酯降低中度剪肾的RPF（-56 +/-3%）和肾小球滤过率（GFR; -54 +/-3%），而这种抑制作用在重度剪肾中消失。相反，中度夹闭时，肾脏PGE（2）含量适度增加，严重夹闭时显著升高（从111 +/- 7至377 +/- 22 pg/ml）;安替比林仅在严重夹闭的肾脏中损害肾脏血流动力学。在对侧未夹闭的肾脏中，尽管肾脏PGE（2）没有增加，但在严重狭窄时，磺比林降低了RPF（-32 +/- 1%）和GFR（-33 +/- 3%）。总的来说，NO在维持基础条件下和中度肾动脉狭窄的肾血流动力学中起着重要作用，而随着肾动脉狭窄的进展，其贡献作用从NO转移到PG。此外，因为据报道，肾内血管紧张素II在非夹闭肾脏中增加，单侧严重缺血可能使非夹闭肾脏对PG抑制敏感。
The role of nitric oxide (NO) and prostaglandins (PG) in modifying renal hemodynamics was examined in clipped and nonclipped kidneys of unilateral renal artery stenosis. Chronic unilateral renal ischemia was established by 4-wk-clipping the left renal artery of canine kidneys, and renal interstitial nitrate+nitrite and PGE(2) contents were evaluated by the microdialysis technique. Unilateral renal artery stenosis caused 45 +/- 1 and 73 +/- 1% decrements in renal plasma flow (RPF) in moderately and severely clipped kidneys and 21 +/- 3% decrements in nonclipped kidneys with severe stenosis. Renal nitrate+nitrite decreased in moderately (-31 +/- 1%) and severely clipped kidneys (-63 +/- 4%). N(omega)-nitro-L-arginine methyl ester reduced RPF (-56 +/- 3%) and glomerular filtration rate (GFR; -54 +/- 3%) in moderately clipped kidneys, whereas this inhibitory effect was abolished in severely clipped kidneys. In contrast, renal PGE(2) contents increased modestly in moderate clipping and were markedly elevated in severely clipped kidneys (from 111 +/- 7 to 377 +/- 22 pg/ml); sulpyrine impaired renal hemodynamics only in severely clipped kidneys. In contralateral nonclipped kidneys, although renal PGE(2) was not increased, sulpyrine reduced RPF (-32 +/- 1%) and GFR (-33 +/- 3%) in severe stenosis. Collectively, NO plays a substantial role in maintaining renal hemodynamics both under basal condition and in moderate renal artery stenosis, whereas the contributory role shifts from NO to PG as renal artery stenosis progresses. Furthermore, because intrarenal angiotensin II is reported to increase in nonclipped kidneys, unilateral severe ischemia may render the nonclipped kidney susceptible to PG inhibition.
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DOI：
10.1681/asn.v16875
发表时间：
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期刊：
Journal of the American Society of Nephrology : JASN
影响因子：
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作者：
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DOI：
10.1152/ajprenal.1992.262.6.f943
发表时间：
1992
期刊：
The American journal of physiology
影响因子：
--
作者：
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通讯作者：
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