OVARIAN-STEROIDS AND MODULATION OF MORPHINE-INDUCED ANALGESIA AND CATALEPSY IN FEMALE RATS
OVARIAN-STEROIDS AND MODULATION OF MORPHINE-INDUCED ANALGESIA AND CATALEPSY IN FEMALE RATS
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DOI：
10.1016/0014-2999(83)90319-9
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发表时间：
1983-01-01
影响因子：
5
通讯作者：
GHOSH, JJ
中科院分区：
文献类型：
--
作者：
BANERJEE, P;CHATTERJEE, TK;GHOSH, JJ
评估了卵巢类固醇对雌性大鼠吗啡镇痛和强直反应调节的影响。动物对吗啡的敏感性在动情周期的不同阶段有所不同。产后和卵巢切除的大鼠对吗啡的反应减弱。雌二醇-17.β的测试剂量。或黄体酮单独或联合使用不会改变这种减弱的吗啡敏感性，而睾酮使产后以及卵巢切除的大鼠对吗啡敏感。与孕酮不同，17-α-羟基孕酮拮抗睾酮。卵巢睾酮可能是雌性大鼠吗啡作用的生理调节剂。
The influence of ovarian steroids on modulation of antinociceptive and cataleptic responses to morphine in female rats was evaluated. The sensitivity of the animals to morphine varied at different stages of the estrous cycle. The responses of postpartum and ovariectomized rats to morphine were attenuated. The test doses of estradiol-17.beta. or progesterone either alone or in combination did not alter this attenuated morphine sensitivity while testosterone sensitized post-partum as well as ovariectomized rats to morphine. Unlike progesterone, 17-.alpha.-hydroxy progesterone antagonized testosterone. Ovarian testosterone may be a physiological modulator of actions of morphine in female rats.