A disturbance of nonlinear interdependence in scalp EEG of subjects with first episode schizophrenia
A disturbance of nonlinear interdependence in scalp EEG of subjects with first episode schizophrenia
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DOI：
10.1016/s1053-8119(03)00332-x
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发表时间：
2003-09-01
期刊：
影响因子：
5.7
通讯作者：
Gordon, E
中科院分区：
文献类型：
--
作者：
Breakspear, M;Terry, JR;Gordon, E
有人提出，精神分裂症是由于大规模皮质系统之间的耦合受到干扰而产生的。这种“断开假设”是通过对头皮脑电图数据应用动态相互依赖的测量来检验的。收集了40名首发精神分裂症患者和40名匹配的健康对照者的脑电图数据。将动态相互依赖检测算法应用于每个受试者的六对双极电极。计算了相互依存的地形组织，并作为皮质整合的主要衡量标准。动态相互依赖的发生率在任何地点的受试者组之间没有统计学差异。然而，两组之间的头皮地形有显著差异。具体来说，与健康受试者相比，精神分裂症患者头皮上的非线性相互依赖倾向于出现在更大的并发“簇”中。这种障碍在左半球内耦合中反映最强烈，根据症状没有显着差异。药物剂量和被试觉醒未被观察到是混杂因素。头皮脑电图数据中动态相互依赖的研究并不支持对断连假说的直接解释，即相邻皮质区域之间的功能耦合强度降低。相反，它表明在跨区域大脑系统的动态相互作用的组织失调。(C) 2003 Elsevier Inc.版权所有。
It has been proposed that schizophrenia arises through a disturbance of coupling between large-scale cortical systems. This "disconnection hypothesis" is tested by applying a measure of dynamical interdependence to scalp EEG data. EEG data were collected from 40 subjects with a first episode of schizophrenia and 40 matched healthy controls. An algorithm for the detection of dynamical interdependence was applied to six pairs of bipolar electrodes in each subject. The topographic organization of the interdependence was calculated and served as the principle measure of cortical integration. The rate of occurrence of dynamical interdependence did not statistically differ between subject groups at any of the sites. However, the topography across the scalp was significantly different between the two groups. Specifically, nonlinear interdependence tended to occur in larger concurrent "clusters" across the scalp in schizophrenia than in the healthy subjects. This disturbance was reflected most strongly in left intrahemispheric coupling and did not differ significantly according to symptomatology. Medication dose and subject arousal were not observed to be confounding factors. The study of dynamical interdependence in scalp EEG data does not support a straightforward interpretation of the disconnection hypothesis-that there is a decrease in the strength of functional coupling between adjacent cortical regions. Rather, it suggests a dysregulation in the organization of dynamical interactions across supraregional brain systems. (C) 2003 Elsevier Inc. All rights reserved.