Relation of Brachial and Digital Measures of Vascular Function in the Community The Framingham Heart Study
Relation of Brachial and Digital Measures of Vascular Function in the Community The Framingham Heart Study
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DOI：
10.1161/hypertensionaha.110.160812
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发表时间：
2011-03-01
期刊：
影响因子：
8.3
通讯作者：
Benjamin, Emelia J.
中科院分区：
文献类型：
--
作者：
Hamburg, Naomi M.;Palmisano, Joseph;Benjamin, Emelia J.
血管功能受损有助于临床心血管疾病的发展。在肱动脉和指动脉中无创评估血管舒张功能之间的关系仍然不完全确定。在FMD后代、第三代和Omni队列中，我们测量了血流介导的扩张（FMD; n=7031;年龄48 ± 13岁;年龄范围19 - 88岁; 54%女性）和外周动脉张力测定（PAT）比率（n=4352; 55 ± 16岁;年龄范围19 - 90岁; 51%女性）。每项测量的异常血管功能定义为无常规心血管危险因素的参考组中的性别特异性第五百分位数。FMD异常率随年龄增长而增高，而PAT异常率随年龄增长而增高。在多变量模型中，体重指数越高，FMD和PAT比值异常的患病率越高。FMD异常的其他相关因素包括年龄增加和收缩压升高。相反，PAT比值异常的相关因素包括收缩压降低、总/高密度脂蛋白胆固醇比值升高、糖尿病、吸烟和降脂药物。然而，女性FMD和PAT比率高于男性，使用性别特异性参考值，女性肱动脉和手指血管功能异常的患病率更高。在同时进行测试的参与者（n=1843）中，PAT比率在多变量模型中与FMD无显著相关性。在这个大型的以社区为基础的队列中，肱动脉和手指血管功能测量与心血管危险因素有不同的关系，并且彼此几乎不相关。这些结果表明，FMD和PAT提供了不同的信息，血管功能的管道与较小的数字血管。（高血压。2011;57：390-396.）。在线补充资料
Impaired vascular function contributes to the development of clinical cardiovascular disease. The relation between vasodilator function assessed noninvasively in the brachial and digital arteries remains incompletely defined. In the Framingham Offspring, Third Generation and Omni Cohorts, we measured flow-mediated dilation (FMD; n=7031; age 48 +/- 13 years; age range, 19 to 88 years; 54% women) and peripheral arterial tonometry (PAT) ratio (n=4352; 55 +/- 16 years; age range, 19 to 90 years; 51% women). Abnormal vascular function for each measure was defined by the sex-specific fifth percentile in a reference group free of conventional cardiovascular risk factors. The prevalence of abnormal FMD but not abnormal PAT ratio was higher with advancing age. In multivariable models, higher body mass index was associated with a higher prevalence of both abnormal FMD and PAT ratio. Additional correlates of abnormal FMD included increasing age and higher systolic blood pressure. In contrast, correlates of abnormal PAT ratio included lower systolic blood pressure, increasing total/high-density lipoprotein cholesterol ratio, diabetes, smoking, and lipid-lowering medication. Whereas women had higher FMD and PAT ratios compared with men, using sex-specific reference values, women had a higher prevalence of abnormal brachial and digital vascular function. In participants who had concurrent testing (n=1843), PAT ratio was not significantly associated with FMD in multivariable models. In this large, community-based cohort, brachial and digital measures of vascular function had differing relations with cardiovascular risk factors and were nearly uncorrelated with each other. These results suggest that FMD and PAT provide distinct information regarding vascular function in conduit versus smaller digital vessels. (Hypertension. 2011;57:390-396.). Online Data Supplement