BONE ALUMINUM CONTENT IN ALZHEIMERS-DISEASE
BONE ALUMINUM CONTENT IN ALZHEIMERS-DISEASE
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DOI：
10.1159/000106924
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发表时间：
1995-03-01
期刊：
影响因子：
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通讯作者：
COAKLEY, D
中科院分区：
文献类型：
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作者：
OMAHONY, D;DENTON, J;COAKLEY, D
铝和阿尔茨海默病之间的可能联系仍然存在争议。如果铝神经毒性与阿尔茨海默病的病理生理学有关，则可能是由于过量铝暴露或脑铝摄取增加所致。在一项初步研究中，以测试前一个假设，骨小梁铝含量，这反映了长期铝暴露，评价了7例患者的临床诊断老年痴呆症的阿尔茨海默型（SDAT;平均年龄80.8 +/- 3.35岁）和19个非痴呆年龄匹配的控制（平均年龄79.6 +/- 6.09岁）。骨小梁取自股骨头假体手术期间患者的创伤后股骨颈骨折标本。骨铝含量用原子吸收分光光度法定量，用酸性铬天青组织染色法定性。定量分析显示，SDAT（11.9 +/- 4.04 μ g/g干骨）中的铝含量低于非痴呆组（18.2 +/- 7.37 μ g/g），在95%置信限下具有显著性，但在99%置信限下不具有显著性。在两组中均未检测到定性组织学分析的铝沉积。这些结果并不支持阿尔茨海默病中铝过度吸收和组织蓄积的假设。
The possible association between aluminium and Alzheimer's disease is still contentious. If aluminium neurotoxicity is implicated in the pathophysiology of Alzheimer's disease, it may result either from excessive aluminium exposure or increased brain aluminium uptake. In a pilot study to test the former hypothesis, trabecular bone aluminium content, which reflects long-term aluminium exposure, was evaluated in 7 patients with a clinical diagnosis of senile dementia of the Alzheimer type (SDAT; mean age 80.8 +/- 3.35 years) and 19 non-demented age-matched controls (mean age 79.6 +/- 6.09 years). Trabecular bone was obtained from post-traumatic femoral neck fracture specimens taken from patients during femoral head prosthesis surgery. Bone aluminium content was expressed quantitatively by atomic absorption spectrometry and qualitatively by the acid solochrome azurine histological staining technique. Quantitative analysis showed a lower aluminium content in the SDAT (11.9 +/- 4.04 mu g/g dry bone) versus the non-demented group (18.2 +/- 7.37 mu g/g), which was significant at the 95% but not at the 99% confidence limit. Aluminium deposition from qualitative histological analysis was not detectable in either group. These results do not support a hypothesis of excessive aluminium absorption and tissue accumulation in Alzheimer's disease.