Factors regulating axon regeneration via JNK MAP kinase in Caenorhabditis elegans
Factors regulating axon regeneration via JNK MAP kinase in Caenorhabditis elegans
复制标题
通过 JNK MAP 激酶调节秀丽隐杆线虫轴突再生的因素
DOI：
10.1093/jb/mvaa020
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Hisamoto Naoki
中科院分区：
文献类型：
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作者：
Shimizu Tatsuhiro;Hisamoto Naoki
神经损伤后的轴突再生是动物中高度保守的过程。线虫是研究轴突再生分子机制的理想模型.最近的研究使用C. elegans的研究表明c-Jun N-末端激酶（JNK）在轴突再生中起重要作用。此外，许多因素已被确定为上游的JNK级联后轴突切断。本文综述了这些因子及其在轴突再生调控中的作用。
Axon regeneration following nerve injury is a highly conserved process in animals. The nematodeCaenorhabditis elegansis an excellent model for investigating the molecular mechanisms of axon regeneration. Recent studies usingC. eleganshave shown that the c-Jun N-terminal kinase (JNK) plays the important role in axon regeneration. Furthermore, many factors have been identified that act upstream of the JNK cascade after axotomy. This review introduces these factors and describes their roles during the regulation of axon regeneration.