Phase-Amplitude Coupling and Long-Range Phase Synchronization Reveal Frontotemporal Interactions during Visual Working Memory
Phase-Amplitude Coupling and Long-Range Phase Synchronization Reveal Frontotemporal Interactions during Visual Working Memory
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DOI：
10.1523/jneurosci.2130-16.2016
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发表时间：
2017-01-11
影响因子：
5.3
通讯作者：
Friese, Uwe
中科院分区：
文献类型：
--
作者：
Daume, Jonathan;Gruber, Thomas;Friese, Uwe
交叉频相幅耦合（PAC）是协调工作记忆储存的一种神经机制，特别是在颞叶脑结构中。在这项脑磁图研究中，我们发现在视觉工作记忆维持过程中，表现出增强PAC的颞叶皮层区域通过增强的低频相位同步与前额叶皮层相互作用。健康的人类参与者参与了一项视觉延迟匹配样本的任务，任务中有自然物体的图片。在延迟期间，我们观察到视觉感觉区β (20-28 Hz)和γ (40-94 Hz)波段的频谱功率增加，而θ / α波段（7-9 Hz）振荡功率下降。在θ / α的相位和β振荡的振幅之间，左颞下叶皮层（IT）被发现有增强的PAC，这是一个已知与视觉对象记忆有关的区域。此外，通过增加θ / α波段内的低频相位同步，IT与前额皮质的功能连接。总之，这些结果指出了一种机制，在这种机制中，PAC和远程相位同步的结合有助于增强大规模的大脑通信。他们认为，通过远程、频内相位同步和局部跨频PAC的结合，远端大脑区域可能在低频范围内协调它们的活动，从而在更高频率上参与局部刺激相关的处理。
It has been suggested that cross-frequency phase-amplitude coupling (PAC), particularly in temporal brain structures, serves as a neural mechanism for coordinated working memory storage. In this magnetoencephalography study, we show that during visual working memory maintenance, temporal cortex regions, which exhibit enhanced PAC, interact with prefrontal cortex via enhanced low-frequency phase synchronization. Healthy human participants were engaged in a visual delayed match-to-sample task with pictures of natural objects. During the delay period, we observed increased spectral power of beta (20-28 Hz) and gamma (40-94 Hz) bands as well as decreased power of theta/alpha band (7-9 Hz) oscillations in visual sensory areas. Enhanced PAC between the phases of theta/alpha and the amplitudes of beta oscillations was found in the left inferior temporal cortex (IT), an area known to be involved in visual object memory. Furthermore, the IT was functionally connected to the prefrontal cortex by increased low-frequency phase synchronization within the theta/alpha band. Together, these results point to a mechanism in which the combination of PAC and long-range phase synchronization subserves enhanced large-scale brain communication. They suggest that distant brain regions might coordinate their activity in the low-frequency range to engage local stimulus-related processing in higher frequencies via the combination of long-range, within-frequency phase synchronization and local cross-frequency PAC.