Comparison of Physician-recorded Toxicities and Patient-reported Outcomes of Five Different Radiotherapy Methods for Prostate Cancer
Comparison of Physician-recorded Toxicities and Patient-reported Outcomes of Five Different Radiotherapy Methods for Prostate Cancer
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DOI：
10.21873/anticanres.15030
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发表时间：
2021-05-01
影响因子：
2
通讯作者：
Yoshioka, Yasuo
中科院分区：
文献类型：
--
作者：
Ito, Makoto;Sasamura, Kazuma;Yoshioka, Yasuo
背景/目的：比较前列腺癌的五种放射治疗方法。患者和方法：对2005-2018年间收治的非转移性前列腺癌患者的临床资料进行回顾性分析。患者接受高剂量率近距离照射(HDR-BT)、低剂量率近距离照射(LDR-BT)或外照射(EBRT)，包括常规分割放射治疗(CFRT)、中分割放射治疗(MHRT)和超分割放射治疗(UHRT)。结果：共纳入496例患者(HDR-BT 149例，LDR-BT 100例，CFRT 100例，MHRT 97例，UHRT 50例)，中位随访时间为4.3年。0.001级的发生率)比任何其他放射治疗都要高。UHRT组晚期2级泌尿生殖系统毒性累积发生率最高，显著高于HDR-BT组(P=0.005)。LDR-BT组治疗后4周的症状评分峰值高于EBRT组。结论：医生记录
Background/Aim: To compare five radiotherapy methods for prostate cancer. Patients and Methods: During 2005-2018, the data of patients with non-metastatic prostate cancer were retrospectively analysed. Patients were treated with high-dose-rate brachytherapy (HDR-BT); low-dose-rate brachytherapy (LDR-BT); or external-beam radiotherapy (EBRT), including conventionally fractionated radiotherapy (CFRT), moderate-hypofractionated radiotherapy (MHRT), and ultra-hypofractionated radiotherapy (UHRT). Results: In total, 496 patients (149, HDR-BT; 100, LDR-BT; 100, CFRT; 97, MHRT, and 50, UHRT) with a median follow-up of 4.3 years were enrolled. The incidence of grade 0.001) than with any other radiotherapy. The cumulative incidence of late grade 2 genitourinary toxicities was the highest with UHRT and significantly higher (p=0.005) with UHRT than with HDR-BT. Higher symptom score peaks were noted 4 weeks after therapy for LDR-BT than for EBRT. Conclusion: Physician-recorded