EVIDENCE FOR A 15-17 TRANSLOCATION IN EVERY PATIENT WITH ACUTE PROMYELOCYTIC LEUKEMIA
EVIDENCE FOR A 15-17 TRANSLOCATION IN EVERY PATIENT WITH ACUTE PROMYELOCYTIC LEUKEMIA
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DOI：
10.1016/0002-9343(84)90994-x
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发表时间：
1984-01-01
影响因子：
5.9
通讯作者：
ROWLEY, JD
中科院分区：
文献类型：
--
作者：
LARSON, RA;KONDO, K;ROWLEY, JD
从27例急性早幼粒细胞白血病患者的血液或骨髓中获得细胞遗传学标本，其中包括4例微颗粒变异。在所有27例患者的21-100%中期细胞中鉴定出15;17易位。在每种情况下，结构重排是相同的，断点被分配到15 q22和17q21.1。12例患者完全缓解，2例（均为微颗粒变异）持续缓解> 4年。如果进行最佳染色体分析，则15;17易位可在每个急性早幼粒细胞白血病患者中发现。
Cytogenetic specimens were obtained from blood or bone marrow in 27 patients with acute promyelocytic leukemia, including 4 with the microgranular variant. A 15;17 translocation was identified in 21-100% of metaphase cells from all 27 patients. The structural rearrangement was identical in every case, and the breakpoints were assigned to 15q22 and 17q21.1. Twelve patients had complete remission, and 2 (both with the microgranular variant) have had unmaintained continuous remission > 4 yr. The 15;17 translocation may be found in every patient with acute promyelocytic leukemia if optimal chromosome analysis is performed.