EFFECT OF PROTEIN-BINDING ON ANTIBIOTIC-ACTIVITY INVIVO
EFFECT OF PROTEIN-BINDING ON ANTIBIOTIC-ACTIVITY INVIVO
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DOI：
10.1093/jac/11.3.233
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发表时间：
1983-01-01
影响因子：
5.2
通讯作者：
ROLINSON, GN
中科院分区：
文献类型：
--
作者：
MERRIKIN, DJ;BRIANT, J;ROLINSON, GN
以一组同属一类的青霉素为材料，采用体内、外抑菌试验，测定了青霉素对金黄色葡萄球菌的抗菌活性。小鼠的感染。这些化合物在体外表现出基本上相同的活性水平，但在体内的活性明显不同。体内的这种活性可能与小鼠血清中蛋白质结合的程度直接相关。
Using a group of penicillins all belonging to the same chemical class, antibacterial activity against Staphylococcus aureus was determined in vitro and in vivo by use of an i.p. infection in mice. The compounds all showed essentially the same level of activity in vitro but differed markedly in their activity in vivo. This activity in vivo could be correlated directly with the extent of protein binding in mouse serum.