Effects of prostaglandin E2 on production of new cancellous bone in the axial skeleton of ovariectomized rats.
Effects of prostaglandin E2 on production of new cancellous bone in the axial skeleton of ovariectomized rats.
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前列腺素 E2 对去卵巢大鼠中轴骨新松质骨生成的影响。
DOI：
10.1016/8756-3282(90)90057-6
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发表时间：
1990
期刊：
影响因子：
4.1
通讯作者：
Kimmel,DB
中科院分区：
文献类型：
--
作者：
Mori,S;Jee,WS;Li,XJ;Chan,S;Kimmel,DB
前列腺素E2（PGE 2）的影响进行了组织形态计量学评价的松质骨的轴骨卵巢切除，骨质疏松大鼠。在3月龄双侧卵巢切除术（OVX）和假卵巢切除术（SHAM）后4个月，每天皮下注射PGE 2 0、0.3、1.0、3.0和6.0 mg/kg/d，持续30天。对未脱钙的第四腰椎椎体（LVB）进行静态和动态骨组织形态计量学处理。OVX大鼠具有轻微骨质减少的LVB（17% vs. 24%松质骨质量）。大鼠连续30天给予3和6 mg/kg/天PGE 2，骨转换、板层骨量和新编织骨小梁形成增加。观察结果支持PGE 2激活骨建模和重建，并改变骨平衡有利于形成的结论。在给予6 mg PGE 2/ kg/天的OVX大鼠中，松质骨质量和骨小梁数量恢复至未治疗的SHAM大鼠中发现的水平。给予3和6 mg PGE 2/ kg/天的SHAM大鼠LVB中的松质骨质量比对照大鼠增加16%和30%。此外，前列腺素E2刺激OVX和SHAM大鼠的纵向骨生长，这一反应与雄性大鼠不同。
The effects of prostaglandin E2(PGE2) were histomorphometrically evaluated in cancellous bone of the axial skeleton of ovariectomized, osteopenic rats. Four months following bilateral ovariectomy (OVX) and sham-ovariectomy (SHAM) at 3 months of age, rats received daily subcutaneous injections of PGE2at 0, 0.3, 1.0, 3.0 and 6.0 mg/kg/day for 30 days. The undecalcified fourth lumbar vertebral bodies (LVB) were processed for static and dynamic bone histomorphometry. The OVX rats possessed a slightly osteopenic LVB (17% vs. 24% cancellous bone mass). In rats given PGE2at 3 and 6 mg/kg/day for 30 days, bone turnover, lamellar bone mass, and formation of new woven bone trabeculae were increased. Observations supported the conclusion that PGE2activates bone modeling and remodeling, and shifts bone balance in favor of formation. In OVX rats given 6 mg PGE2/ kg/day, cancellous bone mass and trabecular numbers were restored to levels found in untreated SHAM rats. Cancellous bone mass in the LVB of SHAM rats given 3 and 6 mg PGE2/ kg/day increased by 16% and 30% over that of control rats. In addition, PGE2stimulated longitudinal bone growth in both OVX and SHAM rats, a response that differed from male rats.