IONIC CURRENTS OF THE LATERAL PYLORIC NEURON OF THE STOMATOGASTRIC GANGLION OF THE CRAB
IONIC CURRENTS OF THE LATERAL PYLORIC NEURON OF THE STOMATOGASTRIC GANGLION OF THE CRAB
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DOI：
10.1152/jn.1992.67.2.318
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发表时间：
1992-02-01
影响因子：
2.5
通讯作者：
MARDER, E
中科院分区：
文献类型：
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作者：
GOLOWASCH, J;MARDER, E
1.幽门外侧(LP)神经元是口胃神经节(STG)幽门节律网络的重要组成部分，也是STG许多调制输入的直接靶点。我们在这篇论文和随后的两篇论文中的目的是描述这个细胞中存在的电导，并了解这些电导在塑造神经元活动中所起的作用。在含有河豚毒素(TTX)和印防己毒素(PTX)的生理盐水中，用双电极电压钳(TEVC)对LP神经元进行研究，从药物上将它们从突触前输入中分离出来。我们确定了六个与电压相关的离子电导。这些电流包括三个类似延迟整流电流的外向电流，一个钙激活的K+电流和一个类似于许多其他制剂中看到的A-电流。LP神经元呈现三种内向电流，一种是快速的TTX敏感电流，一种是超极化激活的内向电流，另一种是钙电流。
1. The lateral pyloric (LP) neuron is an important component of the network that generates the pyloric rhythm of the stomatogastric ganglion (STG) and is a direct target of many modulatory inputs to the STG. Our aim in this and the subsequent two papers is to describe the conductances present in this cell and to understand the role these conductances play in shaping the activity of the neuron.2. LP neurons were studied in two-electrode voltage clamp (TEVC) in a saline solution containing tetrodotoxin (TTX) and picrotoxin (PTX) to isolate them pharmacologically from presynaptic inputs.3. We identified six voltage-dependent ionic conductances. These include three outward currents that resemble a delayed rectifier current, a Ca2+-activated K+ current and an A-current similar to those seen in many other preparations. LP neurons show three inward currents, a fast TTX-sensitive current, a hyperpolarization-activated inward current, and a Ca2+ current.