THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Introduction and Other Protein Targets
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Introduction and Other Protein Targets
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DOI：
10.1111/bph.14747
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发表时间：
2019-12-01
影响因子：
7.3
通讯作者：
Davies, Jamie A.
中科院分区：
文献类型：
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作者：
Alexander, Stephen P. H.;Kelly, Eamonn;Davies, Jamie A.
《简明药理学指南2019/20》是该系列两年期出版物的第四本。简明指南提供了近1800个人类药物靶标的关键特性的简明概述，重点是选择性药理学（如果可用），加上药物靶标及其配体的开放获取知识库来源（www.guidetopharmacology.org）的链接，该资源提供了靶标和配体特性的更详细视图。虽然《简明指南》约有400页，但与网站上提供的信息和链接相比，所提供的材料大大减少。它提供了一个永久的、可引用的时间点记录，可以在数据库更新后继续存在。本节的全部内容可以在http://onlinelibrary.wiley.com/doi/10.1111/bph.14747上找到。除了这一概述，其中确定了其他蛋白质的目标，落在随后的分类之外，有六个重点领域：G蛋白偶联受体，离子通道，核激素受体，催化受体，酶和转运蛋白。这些都提出了命名指南和最佳药理学工具的摘要信息，以及进一步阅读的关键参考和建议。简明指南的横向格式旨在便于比较从当代材料到2019年年中的相关目标，并取代2017/18，2015/16和2013/14简明指南以及之前的接收器和渠道指南中的数据。它与国际基础与临床药理学联合会受体命名和药物分类委员会（NC-IUPHAR）密切合作，因此，在适当情况下为人类药物靶点提供官方IUPHAR分类和命名。
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.14747. In addition to this overview, in which are identified Other protein targets which fall outside of the subsequent categorisation, there are six areas of focus: G protein-coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2019, and supersedes data presented in the 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.