News and views on mitochondrial water transport.

News and views on mitochondrial water transport.
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关于线粒体水运输的新闻和观点。

DOI:
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发表时间:
2009
期刊:
Frontiers in Bioscience
影响因子:
--
通讯作者:
G. Calamita
G. Calamita
中科院分区:
--
文献类型:
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作者:
Patrizia Gena;E. Fanelli;C. Brenner;M. Svelto;G. Calamita

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水进出线粒体基质的渗透运动是线粒体特有的非凡可塑性的基础,这一特征对细胞生物能学和信号传导至关重要,并且与细胞的生死决定至关重要。然而,线粒体水运输的生物物理学和特性仍未被探索,直到最近的研究表明肝线粒体中存在高水渗透性和多种促进水扩散的途径。在这里,我们试图总结我们目前对线粒体水运输机制的看法,以及由线粒体通透性转变、水通道蛋白和蛋白质/脂质专门化产生的通道介导途径的可能相关性。评估线粒体水渗透性的分子基础和动力学将有助于回答有关线粒体作用的备受争议的问题。
The osmotic movement of water into and out of the mitochondrial matrix underlies the extraordinary plasticity that characterizes mitochondria, a feature of pivotal importance to cell bioenergetics and signaling, and of critical relevance to life-and-death cell decision. However, the biophysics and identity of mitochondrial water transport had remained mostly unexplored, until recent works suggesting high water permeability and the presence of multiple facilitated pathways of water diffusion in liver mitochondria. Here, we attempt to summarize our current view of the mechanisms of mitochondrial water transport and possible relevance of the channel-mediated pathways created by mitochondrial permeability transition, aquaporins and protein/lipid specializations. Assessing the molecular bases and dynamics of mitochondrial water permeability will help to answer the much-debated question over the role of mitochondria.
DOI: 10.1016/s0014-5793(01)03314-2
发表时间: 2002-02-13
期刊: FEBS LETTERS
影响因子: 3.5
作者:
He, LH;Lemasters, JJ
通讯作者: Lemasters, JJ
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DOI: 10.1006/abbi.2000.2194
发表时间: 2001
期刊: Archives of biochemistry and biophysics.
影响因子: --
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通讯作者: Sokolove,PM
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影响因子: --
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