News and views on mitochondrial water transport.
News and views on mitochondrial water transport.
复制标题
关于线粒体水运输的新闻和观点。
DOI:
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发表时间:
2009
期刊:
影响因子:
--
通讯作者:
G. Calamita
中科院分区:
文献类型:
--
作者:
Patrizia Gena;E. Fanelli;C. Brenner;M. Svelto;G. Calamita
The osmotic movement of water into and out of the mitochondrial matrix underlies the extraordinary plasticity that characterizes mitochondria, a feature of pivotal importance to cell bioenergetics and signaling, and of critical relevance to life-and-death cell decision. However, the biophysics and identity of mitochondrial water transport had remained mostly unexplored, until recent works suggesting high water permeability and the presence of multiple facilitated pathways of water diffusion in liver mitochondria. Here, we attempt to summarize our current view of the mechanisms of mitochondrial water transport and possible relevance of the channel-mediated pathways created by mitochondrial permeability transition, aquaporins and protein/lipid specializations. Assessing the molecular bases and dynamics of mitochondrial water permeability will help to answer the much-debated question over the role of mitochondria.
影响因子:
3.5
作者:
He, LH;Lemasters, JJ
通讯作者:
Lemasters, JJ
DOI:
10.1006/abbi.2000.2194
发表时间:
2001
期刊:
Archives of biochemistry and biophysics.
影响因子:
--
作者:
Sultan,A;Sokolove,PM
通讯作者:
Sokolove,PM
DOI:
10.1007/978-1-59259-993-6_16
发表时间:
2006
期刊:
Methods in molecular biology (Clifton, N.J.)
影响因子:
--
作者:
Cho,Sang-Joon;Jena,BhanuP
通讯作者:
Jena,BhanuP