Executive and mnemonic functions in early Huntington's disease
Executive and mnemonic functions in early Huntington's disease
复制标题
DOI：
10.1093/brain/119.5.1633
复制
发表时间：
1996-10-01
期刊：
影响因子：
14.5
通讯作者：
Robbins, TW
中科院分区：
文献类型：
--
作者：
Lawrence, AD;Sahakian, BJ;Robbins, TW
研究人员将18名早期亨廷顿氏病患者与年龄和智商匹配的对照组志愿者进行了执行和记忆功能测试，测试数据来自剑桥神经心理测试自动化电池。采用模式和空间识别记忆、空间广度、空间工作记忆、空间规划和视觉辨别学习/注意集转移测试。这些测试先前被发现对亨廷顿氏病的晚期很敏感。早期亨廷顿氏症患者被发现有广泛的认知障碍，包括视觉空间记忆和执行功能，这种模式与其他基底神经节疾病不同。与晚期亨廷顿舞蹈症患者相比，早期亨廷顿舞蹈症患者在简单逆转学习方面没有受损，但在执行外维度转移（EDS）方面受损。结果将讨论与假设的亨廷顿氏病的神经病理分期和纹状体的解剖连接。
Eighteen patients with early Huntington's disease were compared with age- and IQ-matched control volunteers on tests of executive and mnemonic function taken from the Cambridge Neuropsychological Test Automated Battery. Tests of pattern and spatial recognition memory, spatial span, spatial working memory, spatial planning and visual discrimination learning/attentional set shifting were employed. These tests have previously been found to be sensitive to the later stages of Huntington's disease. Patients with early Huntington's disease were found to have a wide range of cognitive impairments encompassing both visuospatial memory and executive functions, a pattern distinct from those seen in other basal ganglia disorders. In contrast to patients with more advanced Huntington's disease, early Huntington's disease patients were not impaired at simple reversal learning, but were impaired at performing an extradimensional shift (EDS). The results will be discussed in relation to the hypothesized neuropathological staging of Huntington's disease and to the anatomical connectivity of the striatum.