Resistance to xenobiotics and parasites: can we count the cost?
Resistance to xenobiotics and parasites: can we count the cost?
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DOI：
10.1016/s0169-5347(00)01929-7
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发表时间：
2000-09-01
影响因子：
16.8
通讯作者：
ffrench-Constant, R
中科院分区：
文献类型：
--
作者：
Coustau, C;Chevillon, C;ffrench-Constant, R
主要效应的单个基因的性质和代价是生物学中持续时间最长的争论之一。抗性，无论是对异源生物还是对寄生虫的抗性，常常被当作一个明显的例子来炫耀，说明单基因效应必然带来相关的适应性“成本”。然而，对异生素抗性文献的回顾表明，这一假设的经验证据实际上是稀缺的。我们假设，这种适应性成本只能根据可能构成其基础的分子突变来充分解释。我们还推导出一个理论框架，以涵盖我们目前对异生物质抗性的理解，并开始剖析寄生虫抗性的可能成本。
The nature and cost of single genes of major effect is one of the longest running controversies in biology. Resistance, whether to xenobiotics or to parasites, is often paraded as an obvious example of a single gene effect that must carry an associated fitness 'cost'. However, a review of the xenobiotic resistance literature shows that empirical evidence for this hypothesis is, in fact, scarce. We postulate that such fitness costs can only be fully interpreted in the light of the molecular mutations that might underlie them. We also derive a theoretical framework both to encompass our current understanding of xenobiotic resistance and to begin to dissect the probable cost of parasite resistance.