ENHANCED PRODUCTION OF SURFACTIN FROM BACILLUS-SUBTILIS BY CONTINUOUS PRODUCT REMOVAL AND METAL CATION ADDITIONS
ENHANCED PRODUCTION OF SURFACTIN FROM BACILLUS-SUBTILIS BY CONTINUOUS PRODUCT REMOVAL AND METAL CATION ADDITIONS
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DOI：
10.1128/aem.42.3.408-412.1981
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发表时间：
1981-01-01
影响因子：
4.4
通讯作者：
KOSARIC, N
中科院分区：
文献类型：
--
作者：
COOPER, DG;MACDONALD, CR;KOSARIC, N
脂肽，表面素，是由枯草芽孢杆菌产生的。对该表面活性剂的规模化生产进行了研究。采用泡沫分馏法连续脱除产物，获得了良好的产率。用酸沉淀法可以很容易地从泡沫破裂中回收表面锡。添加铁盐或锰盐也能提高收率。在培养基中加入碳氢化合物通常会增加生物表面活性剂的产量，但完全抑制了枯草芽孢杆菌表面活性剂的产量。
The lipopeptide, surfactin, is produced by B. subtilis. A study was made on large-scale production of this surfactant. A good yield was obtained from a glucose substrate fermentation by continuously removing the product by foam fractionation. The surfactin could be easily recovered from the collapsed foam by acid precipitation. The yield was also improved by the addition of either Fe or Mn salts. Hydrocarbon addition to the medium, which normally increases biosurfactant production, completely inhibited surfactin production by B. subtilis.