The clinical manifestations and response to treatment in South Africans with lupus nephritis
The clinical manifestations and response to treatment in South Africans with lupus nephritis
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DOI：
10.1177/0961203318770024
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发表时间：
2018-06-01
期刊：
影响因子：
2.6
通讯作者：
Assounga, A.
中科院分区：
文献类型：
--
作者：
Mody, P. G.;Mody, G. M.;Assounga, A.
关于种族对狼疮性肾炎（LN）临床谱和治疗反应的影响，有不同的观察结果。我们研究了一个多种族的南非LN队列，以确定临床表现，组织学参与和治疗反应。我们回顾了德班的Inkosi Albert Luthuli中心医院的LN患者的记录。共有105名患者，92.5%为女性，其中49.1%为印度人，45.3%为非洲黑人。平均年龄为31.3 ± 12.5岁，41.5%的患者在首次出现狼疮时患有LN。最常见的组织学分类为单独的V类（34.9%）、IV类（+/-V类）（25.5%）和III类（+/-V类）（22.6%）。估计肾小球滤过率降低（
There are varying observations on the influence of ethnicity on the clinical spectrum and response to treatment in lupus nephritis (LN). We studied a multiethnic South African LN cohort to determine the clinical manifestations, histological involvement and response to therapy. We reviewed the records of LN patients at Inkosi Albert Luthuli Central Hospital in Durban. There were 105 patients, 92.5% females and they comprised 49.1% Indians and 45.3% African Blacks. The mean age was 31.3 +/- 12.5 years, and 41.5% had LN at first presentation of lupus. The most common histological classes were Class V alone in 34.9%, Class IV (+/- Class V) in 25.5% and Class III (+/- Class V) in 22.6%. The estimated glomerular filtration rate was reduced (