Blood transcriptomic biomarkers of alcohol consumption and cardiovascular disease risk factors: the Framingham Heart Study.
Blood transcriptomic biomarkers of alcohol consumption and cardiovascular disease risk factors: the Framingham Heart Study.
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饮酒和心血管疾病危险因素的血液转录组生物标志物：弗雷明汉心脏研究。
DOI：
10.1093/hmg/ddac237
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发表时间：
2023
影响因子：
3.5
通讯作者：
Liu,Chunyu
中科院分区：
文献类型：
--
作者：
Ma,Jiantao;Huang,Allen;Yan,Kaiyu;Li,Yi;Sun,Xianbang;Joehanes,Roby;Huan,Tianxiao;Levy,Daniel;Liu,Chunyu
背景饮酒与基因表达的关系仍有待阐明。材料和方法我们在 5531 名弗雷明汉心脏研究 (FHS) 参与者中检查了饮酒与全血衍生基因表达水平之间以及酒精相关基因与肥胖、高血压和糖尿病之间的横断面关联。结果我们鉴定了 25 个酒精相关基因。我们进一步显示了 16 个酒精相关基因与肥胖、9 个与高血压相关的基因和 8 个与糖尿病相关的基因的横断面关联，P<0.002。例如，我们观察到PROK2(β= −0.0018; 95%CI: -0.0021, -0.0007;P= 6.5e − 5)和PAX5(β= −0.0014; 95%CI: -0.0021, -0.0007;P= 6.5e − 5) 每增加 1 g/天的酒精消耗量。与我们之前关于饮酒与肥胖呈负相关以及饮酒与高血压呈正相关的观察结果一致，我们发现PROK2与肥胖呈正相关（OR = 1.42；95%CI：1.17，1.72；P= 4.5e − 4），而PAX5与高血压呈负相关（OR = 0.73；95%CI：1.17，1.72；P= 4.5e − 4）。 95%CI: 0.59, 0.89;P= 1.6e − 3)。我们还观察到饮酒与ABCA13的表达呈正相关(β= 0.0012; 95%CI: 0.0007, 0.0017;P= 1.3e − 6)并且ABCA13与糖尿病呈正相关(OR = 2.57; 95%CI: 1.73, 3.84;P= 3.5e − 06);然而，这一发现与我们对饮酒与糖尿病之间负相关的观察结果不一致。结论我们显示，FHS 参与者的饮酒量与 25 个基因的表达水平之间存在很强的横断面关联。尽管如此，酒精相关基因和心血管疾病危险因素之间仍存在复杂的关系。
BackgroundThe relations of alcohol consumption and gene expression remain to be elucidated.Materials and MethodsWe examined cross-sectional associations between alcohol consumption and whole blood derived gene expression levels and between alcohol-associated genes and obesity, hypertension, and diabetes in 5531 Framingham Heart Study (FHS) participants.ResultsWe identified 25 alcohol-associated genes. We further showed cross-sectional associations of 16 alcohol-associated genes with obesity, nine genes with hypertension, and eight genes with diabetes atP< 0.002. For example, we observed decreased expression ofPROK2(β= −0.0018; 95%CI: −0.0021, −0.0007;P= 6.5e − 5) andPAX5(β= −0.0014; 95%CI: −0.0021, −0.0007;P= 6.5e − 5) per 1 g/day increase in alcohol consumption. Consistent with our previous observation on the inverse association of alcohol consumption with obesity and positive association of alcohol consumption with hypertension, we found thatPROK2was positively associated with obesity (OR = 1.42; 95%CI: 1.17, 1.72;P= 4.5e − 4) andPAX5was negatively associated with hypertension (OR = 0.73; 95%CI: 0.59, 0.89;P= 1.6e − 3). We also observed that alcohol consumption was positively associated with expression ofABCA13(β= 0.0012; 95%CI: 0.0007, 0.0017;P= 1.3e − 6) andABCA13was positively associated with diabetes (OR = 2.57; 95%CI: 1.73, 3.84;P= 3.5e − 06); this finding, however, was inconsistent with our observation of an inverse association between alcohol consumption and diabetes.ConclusionsWe showed strong cross-sectional associations between alcohol consumption and expression levels of 25 genes in FHS participants. Nonetheless, complex relationships exist between alcohol-associated genes and CVD risk factors.