Reduction of thrombosis in canine coronary bypass vein grafts with dipyridamole and aspirin.
Reduction of thrombosis in canine coronary bypass vein grafts with dipyridamole and aspirin.
复制标题
使用双嘧达莫和阿司匹林减少犬冠状动脉旁路静脉移植物中的血栓形成。
DOI：
10.1016/0002-9149(81)90254-x
复制
发表时间：
1981
期刊：
影响因子：
--
通讯作者：
M. Kaye
中科院分区：
文献类型：
--
作者：
M. Josa;J. Lie;R. Bianco;M. Kaye
在犬中评估了血小板抑制剂药物在减少冠状动脉静脉旁路移植术早期血栓形成方面的潜在益处。有26只对照犬和24只犬接受双嘧达莫（55 mg/天）加阿司匹林（325 mg/天）治疗。两组均于术后2 h、1、2、3、7、14 d处死。移植物在体内用flxative灌注，收获并用光学显微镜检查。两组犬的移植物壁均观察到严重变化。对照组移植物血栓形成发生率较高，发生在术后早期;治疗组移植物血栓形成发生率显著降低（p = 0.025）。我们的研究表明，双嘧达莫和阿司匹林的联合方案是有效的，以减少早期移植物血栓形成的狗。
The potential benefit of platelet inhibitor drugs in reducing early thrombosis of coronary arterial vein bypass grafts was assessed in dogs. There were 26 control dogs and 24 dogs treated with dipyridamole, 55 mg/day plus aspirin, 325 mg/day. The dogs in both groups were killed at 2 hours and 1, 2, 3, 7 and 14 days after operation. The grafts were perfused with flxative in vivo, harvested and examined with light microscopy. Severe alterations of the graft wall were observed in the dogs in both groups. The grafts in the control group had a high incidence rate of thrombosis, which occurred early after the operation; those in the treated group had a significantly reduced incidence of thrombosis (p = 0.025). Our study indicates that a combined regimen of dipyridamole and aspirin is effective in reducing early graft thrombosis in dogs.