Association between IL-35 and coronary arterial lesions in children with Kawasaki disease
Association between IL-35 and coronary arterial lesions in children with Kawasaki disease
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IL-35与川崎病儿童冠状动脉病变的关系
DOI：
10.1007/s10238-018-0513-6
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发表时间：
2019-02-01
影响因子：
4.6
通讯作者：
Yi, Qijian
中科院分区：
文献类型：
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作者：
Su, Ya;Feng, Siqi;Yi, Qijian
川崎（Kawasaki disease，KD）是由急性炎症和免疫系统功能紊乱引起的。本研究旨在探讨川崎病患者血清IL-35水平与冠状动脉病变的关系。我们在静脉注射免疫球蛋白治疗前采集了90例KD患儿的血液样本。检测190例KD患儿血清IL-35、IL-6、IL-17 A、IL-10、MCP-1和VEGF水平，其中KD合并冠状动脉病变组（n= 46）、KD无冠状动脉病变组（n= 44）、发热对照组（n= 40）和正常对照组（n= 60）。所有受试者均检测白色细胞计数（WBC）、红细胞计数（RBC）、血红蛋白、血小板、C反应蛋白（CRP）、红细胞沉降率（ESR）和降钙素原。与发热组和对照组相比，KD组IL-35、RBC和血红蛋白水平显著降低，IL-6、IL-17 A、IL-10、MCP-1和VEGF水平显著升高。伴CAL的KD患者血清IL-35水平更低，ESR、IL-6、MCP-1和VEGF水平更高。KD患儿血清IL-35水平与WBC、CRP、IL-6、IL-17 A、IL-10、MCP-1、VEGF呈负相关。IL-35可能具有抑制KD炎症反应的作用，从而预防KD患者冠状动脉病变的发生。
Kawasaki disease (KD) arises due to the acute inflammation and immune system dysfunction. This study investigated the relationship between the serum level of IL-35 and coronary artery lesions (CALs) in patients with KD. We obtained blood samples from 90 children with KD before intravenous immunoglobulin therapy. Levels of IL-35, IL-6, IL-17A, IL-10, MCP-1 and VEGF were measured in 190 cases, including 4 groups: KD with coronary arterial lesions (n= 46), KD without coronary arteries lesions (n= 44), febrile control group (FC,n= 40) and the normal control group (NC,n= 60). White blood cell counts (WBC), red blood cell counts (RBC), hemoglobin, platelet, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and procalcitonin were tested in all subjects. Levels of IL-35, RBC and hemoglobin significantly decreased, and IL-6, IL-17A, IL-10, MCP-1 and VEGF were significantly elevated in the KD group compared with febrile and control groups. IL-35 serum level even decreased, and ESR, IL-6, MCP-1 and VEGF increased in the KD patients with CALs. Serum levels of IL-35 in KD patients were negatively associated with WBC, CRP, IL-6, IL-17A, IL-10, MCP-1 and VEGF in children with KD. IL-35 may have the effect on inhibiting inflammatory process in KD and further preventing KD patients from coronary artery lesion.