Acute anxiogenic-like effects of selective serotonin reuptake inhibitors are attenuated by the benzodiazepine diazepam in BALB/c mice.
Acute anxiogenic-like effects of selective serotonin reuptake inhibitors are attenuated by the benzodiazepine diazepam in BALB/c mice.
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DOI：
10.1016/j.pbb.2011.03.006
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发表时间：
2011-06
期刊：
影响因子：
--
通讯作者：
Rowlett JK
中科院分区：
文献类型：
--
作者：
Birkett MA;Shinday NM;Kessler EJ;Meyer JS;Ritchie S;Rowlett JK
通常用于治疗焦虑症的选择性5-羟色胺再摄取抑制剂（SSRI）在急性给药后具有特征性的致焦虑作用。抗焦虑苯二氮卓类药物（BZ）治疗可能会减少这些影响，尽管对潜在的药物相互作用知之甚少。我们的研究评估了SSRIs单独使用和与BZ联合使用的急性焦虑样作用。成年雄性Balb/c小鼠接受氟西汀（3.0-30.0 mg/kg，腹腔注射）或西酞普兰（3.0- 30.0mg/kg，i. p.）单独或与地西泮（0.3-10.0 mg/kg，i. p.）组合，然后用光/暗和旷场试验评价它们的焦虑发生/抗焦虑作用。此外，在SSRI/BZ联合给药后评估了应激激素皮质酮的释放。在明/暗和旷场试验中，急性SSRIs产生了与焦虑发生一致的行为特征，而地西泮产生了抗焦虑样特征。地西泮（0.3-10 mg/kg）预处理可逆转焦虑样剂量SSRI（18 mg/kg氟西汀，30 mg/kg西酞普兰）在明/暗和旷场试验中的作用。地西泮、氟西汀或西酞普兰以及它们的组合均以相同程度显著增加血浆皮质酮水平。这些发现表明，BZ型药物可以通过独立于皮质酮调节的机制减弱SSRI的急性致焦虑样作用。
Selective serotonin re-uptake inhibitors (SSRIs), which are used commonly to treat anxiety disorders, have characteristic anxiogenic effects following acute administration. Treatment with anxiolytic benzodiazepines (BZs) may reduce these effects, although little is known about potential drug interactions. Our study evaluated acute anxiogenic–like effects of SSRIs, alone and combined with a BZ. Adult male BALB/c mice received fluoxetine (3.0–30.0 mg/kg, i.p.) or citalopram (3.0–30.0 mg/kg, i.p.) alone or in combination with diazepam (0.3–10.0 mg/kg, i.p.), after which they were evaluated with the light/dark and open-field tests for anxiogenesis/anxiolysis. In addition, release of the stress hormone corticosterone was assessed following combined SSRI/BZ administration. In the light/dark and open-field tests, acute SSRIs produced a behavioral profile consistent with anxiogenesis, while diazepam produced an anxiolytic-like profile. Pre-treatment with diazepam (0.3–10 mg/kg) reversed the effects of an anxiogenic-like dose of an SSRI (18 mg/kg fluoxetine, 30 mg/kg citalopram) in both light/dark and open-field tests. Diazepam, fluoxetine or citalopram, and their combination all significantly increased plasma corticosterone levels to the same degree. These findings suggest that a BZ-type drug can attenuate acute anxiogenic-like effects of an SSRI via a mechanism independent of corticosterone regulation.
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DOI：
10.1017/s1461145701002632
发表时间：
2001-12-01
影响因子：
4.8
作者：
Bagdy, G;Graf, M;Kantor, S
通讯作者：
Kantor, S
影响因子：
3.7
作者：
Kalman, BA;Kim, PJ;Spencer, RL
通讯作者：
Spencer, RL
影响因子：
7.6
作者：
Koch, S;Perry, KW;Bymaster, FP
通讯作者：
Bymaster, FP
影响因子：
3.7
作者：
Fries, Eva;Hellhammer, Dirk H.;Hellhammer, Juliane
通讯作者：
Hellhammer, Juliane
影响因子：
7.2
作者：
Benitez, Carlos Israel Perez;Smith, Kevin;Keller, Martin B.
通讯作者：
Keller, Martin B.